| http://purl.uniprot.org/citations/16822931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16822931 | http://www.w3.org/2000/01/rdf-schema#comment | "Caveolin-1 associates with store-operated cation channels (SOC) in endothelial cells. We examined the role of the caveolin-1 scaffolding domain (CSD) in regulating the SOC [i.e., transient receptor potential channel-1 (TRPC1)] in human pulmonary artery endothelial cells (HPAECs). We used the cell-permeant antennapedia (AP)-conjugated CSD peptide, which competes for protein binding partners with caveolin-1, to assess the interactions of caveolin-1 with TRPC1 and its consequences on thrombin-induced Ca2+ influx. We observed that AP-CSD peptide markedly reduced thrombin-induced Ca2+ influx via SOC in HPAECs in contrast to control peptide. AP-CSD also suppressed thapsigargin-induced Ca2+ influx. Streptavidin-bead pull-down assay indicated strong binding of biotin-labeled AP-CSD peptide to TRPC1. Immunoprecipitation studies demonstrated an interaction between endogenous TRPC1 and ectopically expressed hemagglutinin-tagged CSD. Analysis of the deduced TRPC1 amino acid sequence revealed the presence of CSD binding consensus sequence in the TRPC1 C terminus. We also observed that an AP-TRPC1 peptide containing the CSD binding sequence markedly reduced the thrombin-induced Ca2+ influx. We identified the interaction between biotin-labeled AP-TRPC1 C terminus peptide and caveolin-1. Thus, these results demonstrate a crucial role of caveolin-1 scaffolding domain interaction with TRPC1 in regulating Ca2+ influx via SOC."xsd:string |
| http://purl.uniprot.org/citations/16822931 | http://purl.org/dc/terms/identifier | "doi:10.1124/mol.105.021741"xsd:string |
| http://purl.uniprot.org/citations/16822931 | http://purl.uniprot.org/core/author | "Skidgel R.A."xsd:string |
| http://purl.uniprot.org/citations/16822931 | http://purl.uniprot.org/core/author | "Malik A.B."xsd:string |
| http://purl.uniprot.org/citations/16822931 | http://purl.uniprot.org/core/author | "Minshall R.D."xsd:string |
| http://purl.uniprot.org/citations/16822931 | http://purl.uniprot.org/core/author | "Tiruppathi C."xsd:string |
| http://purl.uniprot.org/citations/16822931 | http://purl.uniprot.org/core/author | "Cool D.R."xsd:string |
| http://purl.uniprot.org/citations/16822931 | http://purl.uniprot.org/core/author | "Kwiatek A.M."xsd:string |
| http://purl.uniprot.org/citations/16822931 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16822931 | http://purl.uniprot.org/core/name | "Mol Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/16822931 | http://purl.uniprot.org/core/pages | "1174-1183"xsd:string |
| http://purl.uniprot.org/citations/16822931 | http://purl.uniprot.org/core/title | "Caveolin-1 regulates store-operated Ca2+ influx by binding of its scaffolding domain to transient receptor potential channel-1 in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/16822931 | http://purl.uniprot.org/core/volume | "70"xsd:string |
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