| http://purl.uniprot.org/citations/1682321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1682321 | http://www.w3.org/2000/01/rdf-schema#comment | "Saccharomyces cerevisiae replication factor C (RF-C) was purified 25,000-fold from a protease-deficient strain of yeast. RF-C is a complex of 6 subunits of 130, 86, 41, 40, 37, and 27 kDa. None of the subunits are related through proteolysis or differential phosphorylation. The assay for RF-C used as a substrate single-stranded DNA binding protein-coated singly primed single-stranded mp 18 DNA. This DNA was poorly replicated by yeast DNA polymerase delta with or without its cofactor proliferating cell nuclear antigen (PCNA). In the presence of RF-C, however, replication of the template proceeded efficiently when both ATP and PCNA were present as well. Formation of this replication-proficient complex of DNA polymerase delta required an input of one to two molecules of PCNA per replicated DNA molecule. DNA polymerase epsilon also formed an ATP-dependent complex with PCNA and RF-C. RF-C has a DNA-dependent ATPase activity, equally active on single-stranded and primed single-stranded mp18 DNA. Addition of PCNA stimulated the ATPase of RF-C on primed but not on unprimed DNA, indicating that the increase in ATPase was due to PCNA-enhanced binding of RF-C to the primer terminus. Calf thymus PCNA also stimulated the ATPase activity of yeast RF-C and participated in holoenzyme formation with DNA polymerase delta. These results attest to the structural and functional homology between yeast and mammalian cells for these components of the replication machinery."xsd:string |
| http://purl.uniprot.org/citations/1682321 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)54624-x"xsd:string |
| http://purl.uniprot.org/citations/1682321 | http://purl.uniprot.org/core/author | "Burgers P.M."xsd:string |
| http://purl.uniprot.org/citations/1682321 | http://purl.uniprot.org/core/author | "Yoder B.L."xsd:string |
| http://purl.uniprot.org/citations/1682321 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1682321 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/1682321 | http://purl.uniprot.org/core/pages | "22689-22697"xsd:string |
| http://purl.uniprot.org/citations/1682321 | http://purl.uniprot.org/core/title | "Saccharomyces cerevisiae replication factor C. I. Purification and characterization of its ATPase activity."xsd:string |
| http://purl.uniprot.org/citations/1682321 | http://purl.uniprot.org/core/volume | "266"xsd:string |
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