| http://purl.uniprot.org/citations/16823445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16823445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16823445 | http://www.w3.org/2000/01/rdf-schema#comment | "Much remains unknown about the molecular regulation of meiosis. Here we show that meiosis-specific transcripts are selectively removed if expressed during vegetative growth in fission yeast. These messenger RNAs contain a cis-acting region--which we call the DSR--that confers this removal via binding to a YTH-family protein Mmi1. Loss of Mmi1 function severely impairs cell growth owing to the untimely expression of meiotic transcripts. Microarray analysis reveals that at least a dozen such meiosis-specific transcripts are eliminated by the DSR-Mmi1 system. Mmi1 remains in the form of multiple nuclear foci during vegetative growth. At meiotic prophase these foci precipitate to a single focus, which coincides with the dot formed by the master meiosis-regulator Mei2. A meiotic arrest due to the loss of the Mei2 dot is released by a reduction in Mmi1 activity. We propose that Mei2 turns off the DSR-Mmi1 system by sequestering Mmi1 to the dot and thereby secures stable expression of meiosis-specific transcripts."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature04881"xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature04881"xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Tanaka H."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Tanaka H."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Watanabe Y."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Watanabe Y."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Yamashita A."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Yamashita A."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Chikashige Y."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Chikashige Y."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Hiraoka Y."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Hiraoka Y."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Yamanaka S."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Yamanaka S."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Tsutsumi C."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Tsutsumi C."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Harigaya Y."xsd:string |
| http://purl.uniprot.org/citations/16823445 | http://purl.uniprot.org/core/author | "Harigaya Y."xsd:string |