| http://purl.uniprot.org/citations/16823849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16823849 | http://www.w3.org/2000/01/rdf-schema#comment | "The GATA family of transcription factors promotes the normal development of the gastrointestinal tract during embryogenesis and determines tissue differentiation in adult gut epithelium. Loss of GATA-4 and GATA-5 has been reported in human gastric and colon cancer. We examined GATA-4,-5 and -6 gene expression in established esophageal squamous cancer cell lines and the relationship to DNA methylation in the promoter region of these genes. GATA-4 and GATA-5 expression was absent in most esophageal cancer cell lines, but was restored upon treatment with the demethylating agent 5-aza-2'-deoxycytidine. For each of the cell lines without detectable GATA gene expression, aberrant methylation of the promoter region CpG-island was detected by methylation specific PCR. We confirmed these results with genomic bisulfite sequencing. GATA-6 expression was found in each of the cell lines. GATA-4/-5 promoter methylation was not detected in normal esophageal mucosa, but GATA-4 methylation was present in 27 of 44 (61%) squamous carcinomas and 31 of 44 (71%) adenocarcinoma of the esophagus, while GATA-5 methylation was present in 14 of 44 (32%) squamous carcinomas and 24 of 44 (55%) adenocarcinoma of the esophagus. Our studies demonstrate frequent silencing of GATA-4 and GATA-5, but not GATA-6, in human esophageal neoplasia associated with gene promoter hypermethylation."xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.22092"xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/author | "Guo M."xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/author | "Harmon J."xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/author | "Qi Y."xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/author | "Akiyama Y."xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/author | "Baylin S.B."xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/author | "Herman J.G."xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/author | "Brock M.V."xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/author | "House M.G."xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/author | "Capagna D."xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/pages | "2078-2083"xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/title | "Hypermethylation of the GATA gene family in esophageal cancer."xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/16823849 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16823849 |
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| http://purl.uniprot.org/uniprot/#_B0LXF1-mappedCitation-16823849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16823849 |