| http://purl.uniprot.org/citations/16825495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16825495 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies showed that most cases of ALK(+) anaplastic large-cell lymphoma (ALK(+)ALCL) do not express SHP1, a tyrosine phosphatase and an important negative regulator for cellular signaling pathways such as that of JAK/STAT. To fully assess the biologic significance of loss of SHP1 in ALK(+)ALCL, we transfected SHP1 plasmids into 2 SHP1(-), ALK(+)ALCL cell lines, Karpas 299 and SU-DHL-1. After 24 hours of transfection, pJAK3 and pSTAT3 were decreased, and these changes correlated with down-regulation of STAT3 downstream targets including cyclin D3, mcl-1, and bcl-2. Expression of SHP1 in these 2 cell lines also resulted in marked decreases in the protein levels of JAK3 and NPM-ALK, and these effects were reversible by proteosome inhibitor MG132. Conversely, when SHP1 expression in SUP-M2 (a SHP1(+) ALK(+)ALCL cell line) was inhibited using siRNA, pSTAT3, pJAK3, JAK3, and NPM-ALK were all up-regulated. Coimmunoprecipitation studies showed that SHP1 was physically associated with JAK3 and NPM-ALK. SHP1 expression in Karpas 299 and SU-DHL-1 led to significant G(1) cell cycle arrest but not apoptosis. To conclude, loss of SHP1 contributes to the pathogenesis of ALK(+)ALCL by 2 mechanisms: (1) it leaves the tyrosine phosphorylation and activation of JAK3/STAT3 unchecked and (2) it decreases proteosome degradation of JAK3 and NPM-ALK."xsd:string |
| http://purl.uniprot.org/citations/16825495 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-04-017434"xsd:string |
| http://purl.uniprot.org/citations/16825495 | http://purl.uniprot.org/core/author | "Han Y."xsd:string |
| http://purl.uniprot.org/citations/16825495 | http://purl.uniprot.org/core/author | "Lai R."xsd:string |
| http://purl.uniprot.org/citations/16825495 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/16825495 | http://purl.uniprot.org/core/author | "Amin H.M."xsd:string |
| http://purl.uniprot.org/citations/16825495 | http://purl.uniprot.org/core/author | "Frantz C."xsd:string |
| http://purl.uniprot.org/citations/16825495 | http://purl.uniprot.org/core/author | "Franko B."xsd:string |
| http://purl.uniprot.org/citations/16825495 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16825495 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16825495 | http://purl.uniprot.org/core/pages | "2796-2803"xsd:string |
| http://purl.uniprot.org/citations/16825495 | http://purl.uniprot.org/core/title | "Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/16825495 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/16825495 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16825495 |
| http://purl.uniprot.org/citations/16825495 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16825495 |
| http://purl.uniprot.org/uniprot/#_A0A0K2YUJ3-mappedCitation-16825495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16825495 |
| http://purl.uniprot.org/uniprot/#_A0A140VJQ2-mappedCitation-16825495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16825495 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4R7-mappedCitation-16825495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16825495 |
| http://purl.uniprot.org/uniprot/#_D1MAM4-mappedCitation-16825495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16825495 |
| http://purl.uniprot.org/uniprot/#_D1MAM5-mappedCitation-16825495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16825495 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z485-mappedCitation-16825495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16825495 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z491-mappedCitation-16825495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16825495 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4G7-mappedCitation-16825495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16825495 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V395-mappedCitation-16825495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16825495 |