| http://purl.uniprot.org/citations/16825657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16825657 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinases (MMPs) are a family of extracellular proteases that are responsible for the degradation of the extracellular matrix during tissue remodeling. We have used a mouse model of allergen-induced airway remodeling to determine whether MMP-9 plays a role in airway remodeling. MMP-9-deficient and wild-type (WT) mice were repetitively challenged intranasally with ovalbumin (OVA) antigen to develop features of airway remodeling including peribronchial fibrosis and increased thickness of the peribronchial smooth muscle layer. OVA-challenged MMP-9-deficient mice had less peribronchial fibrosis and total lung collagen compared with OVA-challenged WT mice. There was no reduction in mucus expression, smooth muscle thickness, or airway responsiveness in OVA-challenged MMP-9-deficient compared with OVA-challenged WT mice. OVA-challenged MMP-9-deficient mice had reduced levels of bronchoalveolar lavage (BAL) regulated on activation, normal T cell expressed, and secreted (RANTES), as well as reduced numbers of BAL and peribronchial eosinophils compared with OVA-challenged WT mice. There were no significant difference in levels of BAL eotaxin, thymus- and activation-regulated chemokine (TARC), or macrophage-derived chemokine (MDC) in OVA-challenged WT compared with MMP-9-deficient mice. Overall, this study demonstrates that MMP-9 may play a role in mediating selected aspects of allergen-induced airway remodeling (i.e., modest reduction in levels of peribronchial fibrosis) but does not play a significant role in mucus expression, smooth muscle thickness, or airway responsiveness."xsd:string |
| http://purl.uniprot.org/citations/16825657 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.00305.2005"xsd:string |
| http://purl.uniprot.org/citations/16825657 | http://purl.uniprot.org/core/author | "Miller M."xsd:string |
| http://purl.uniprot.org/citations/16825657 | http://purl.uniprot.org/core/author | "Cho J.Y."xsd:string |
| http://purl.uniprot.org/citations/16825657 | http://purl.uniprot.org/core/author | "Lim D.H."xsd:string |
| http://purl.uniprot.org/citations/16825657 | http://purl.uniprot.org/core/author | "Broide D.H."xsd:string |
| http://purl.uniprot.org/citations/16825657 | http://purl.uniprot.org/core/author | "McElwain K."xsd:string |
| http://purl.uniprot.org/citations/16825657 | http://purl.uniprot.org/core/author | "McElwain S."xsd:string |
| http://purl.uniprot.org/citations/16825657 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16825657 | http://purl.uniprot.org/core/name | "Am J Physiol Lung Cell Mol Physiol"xsd:string |
| http://purl.uniprot.org/citations/16825657 | http://purl.uniprot.org/core/pages | "L265-71"xsd:string |
| http://purl.uniprot.org/citations/16825657 | http://purl.uniprot.org/core/title | "Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/16825657 | http://purl.uniprot.org/core/volume | "291"xsd:string |
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