| http://purl.uniprot.org/citations/16828866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16828866 | http://www.w3.org/2000/01/rdf-schema#comment | "CD33 (Siglec-3) is expressed on most acute myeloid leukemia (AML) cells and is currently being exploited as a therapeutic target. The purpose of this study was to investigate the expression pattern and potential utility of the seven recently described CD33-related siglecs as markers in AML. Besides CD33, Siglec-9 was the most highly expressed, particularly on AML cells with features of monocytic differentiation that also expressed Siglecs-5 and -7. Siglec-9 was absent from normal bone marrow myeloid progenitors but present on monocytic precursors. Using primary AML cells or transfected rat basophilic leukemia cells, Siglec-9 mediated rapid endocytosis of anti-Siglec-9 mAb. In contrast to CD33 and Siglec-5, levels of soluble Siglec-9 were low or undetectable in bone marrow plasma from AML patients and serum from normal donors. These features suggest that Siglec-9 provides not only a useful marker for certain subsets of AML, but also a potential therapeutic target."xsd:string |
| http://purl.uniprot.org/citations/16828866 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.leukres.2006.05.026"xsd:string |
| http://purl.uniprot.org/citations/16828866 | http://purl.uniprot.org/core/author | "Crocker P.R."xsd:string |
| http://purl.uniprot.org/citations/16828866 | http://purl.uniprot.org/core/author | "Gil D."xsd:string |
| http://purl.uniprot.org/citations/16828866 | http://purl.uniprot.org/core/author | "Biedermann B."xsd:string |
| http://purl.uniprot.org/citations/16828866 | http://purl.uniprot.org/core/author | "Bowen D.T."xsd:string |
| http://purl.uniprot.org/citations/16828866 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/16828866 | http://purl.uniprot.org/core/name | "Leuk Res"xsd:string |
| http://purl.uniprot.org/citations/16828866 | http://purl.uniprot.org/core/pages | "211-220"xsd:string |
| http://purl.uniprot.org/citations/16828866 | http://purl.uniprot.org/core/title | "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors."xsd:string |
| http://purl.uniprot.org/citations/16828866 | http://purl.uniprot.org/core/volume | "31"xsd:string |
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| http://purl.uniprot.org/uniprot/#_O15389-mappedCitation-16828866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16828866 |
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| http://purl.uniprot.org/uniprot/O15389 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16828866 |
| http://purl.uniprot.org/uniprot/Q9Y286 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16828866 |