| http://purl.uniprot.org/citations/16831557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16831557 | http://www.w3.org/2000/01/rdf-schema#comment | "Axon growth inhibitory CNS matrix proteins, such as tenascin-R (TN-R), have been supposed to contribute to the poor regenerative capacity of adult mammalian CNS. With regard to TN-R function in low vertebrates capable of CNS regeneration, questions of particular interest concern the (co)evolution of ligand-receptor pairs and cellular response mechanisms associated with axon growth inhibition and oligodendrocyte differentiation. We address here these questions in a series of comparative in vivo and in vitro analyses using TN-R proteins purified from different vertebrates (from fish to human). Our studies provide strong evidence that unlike TN-R of higher vertebrates, fish TN-R proteins are not repellent for fish and less repellent for mammalian neurons and do not interfere with F3/contactin- and fibronectin-mediated mammalian cell adhesion and axon growth. However, axonal repulsion is induced in fish neurons by mammalian TN-R proteins, suggesting that the intracellular inhibitory machinery induced by TN-R-F3 interactions is already present during early vertebrate evolution. In contrast to TN-R-F3, TN-R-sulfatide interactions, mediating oligodendrocyte adhesion and differentiation, are highly conserved during vertebrate evolution. Our findings thus indicate the necessity of being cautious about extrapolations of the function of ligand-receptor pairs beyond a species border and, therefore, about the phylogenetic conservation of a molecular function at the cellular/tissue level."xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2006.05.008"xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/author | "Lang D.M."xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/author | "McBride R."xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/author | "Spiess E."xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/author | "Gennarini G."xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/author | "Pesheva P."xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/author | "Probstmeier R."xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/author | "Hsu N.J."xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/author | "Peshev Z."xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/name | "Mol Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/pages | "366-386"xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/title | "Early coevolution of adhesive but not antiadhesive tenascin-R ligand-receptor pairs in vertebrates: a phylogenetic study."xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/16831557 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16831557 |
| http://purl.uniprot.org/citations/16831557 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16831557 |
| http://purl.uniprot.org/uniprot/Q8BYI9#attribution-5E18D72F32A68823B6F7670D2FB736FA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16831557 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWD9-mappedCitation-16831557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16831557 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWY3-mappedCitation-16831557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16831557 |
| http://purl.uniprot.org/uniprot/#_Q8BYI9-mappedCitation-16831557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16831557 |
| http://purl.uniprot.org/uniprot/Q8BYI9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16831557 |
| http://purl.uniprot.org/uniprot/A0A0A6YWD9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16831557 |
| http://purl.uniprot.org/uniprot/A0A0A6YWY3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16831557 |