| http://purl.uniprot.org/citations/16835262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16835262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16835262 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations resulting in the expansion of a polyglutamine tract in the protein ataxin-2 give rise to the neurodegenerative disorders spinocerebellar ataxia type 2 and Parkinson's disease. The normal cellular function of ataxin-2 and the mechanism by which polyglutamine expansion of ataxin-2 causes neurodegeneration are unknown. Here, we demonstrate that ataxin-2 and its Drosophila homolog, ATX2, assemble with polyribosomes and poly(A)-binding protein (PABP), a key regulator of mRNA translation. The assembly of ATX2 with polyribosomes is mediated independently by two distinct evolutionarily conserved regions of ATX2: an N-terminal Lsm/Lsm-associated domain (LsmAD), found in proteins that function in nuclear RNA processing and mRNA decay, and a PAM2 motif, found in proteins that interact physically with PABP. We further show that the PAM2 motif mediates a physical interaction of ATX2 with PABP in addition to promoting ATX2 assembly with polyribosomes. Our results suggest a model in which ATX2 binds mRNA directly through its Lsm/LsmAD domain and indirectly via binding PABP that is itself directly bound to mRNA. These findings, coupled with work on other ataxin-2 family members, suggest that ATX2 plays a direct role in translational regulation. Our results raise the possibility that polyglutamine expansions within ataxin-2 cause neurodegeneration by interfering with the translational regulation of particular mRNAs."xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddl173"xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddl173"xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/author | "Pallanck L.J."xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/author | "Pallanck L.J."xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/author | "Satterfield T.F."xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/author | "Satterfield T.F."xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/pages | "2523-2532"xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/pages | "2523-2532"xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/title | "Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes."xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/title | "Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes."xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/16835262 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16835262 |
| http://purl.uniprot.org/citations/16835262 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16835262 |
| http://purl.uniprot.org/citations/16835262 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16835262 |
| http://purl.uniprot.org/citations/16835262 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16835262 |
| http://purl.uniprot.org/uniprot/Q99700 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16835262 |
| http://purl.uniprot.org/uniprot/Q99700#attribution-1317A768F420D412F91B69FB36DC9EA7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16835262 |