| http://purl.uniprot.org/citations/16840721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16840721 | http://www.w3.org/2000/01/rdf-schema#comment | "The endoglin heterozygous (Eng(+/-)) mouse, which serves as a model of hereditary hemorrhagic telangiectasia (HHT), was shown to express reduced levels of endothelial NO synthase (eNOS) with impaired activity. Because of intricate changes in vasomotor function in the Eng(+/-) mice and the potential interactions between the NO- and prostaglandin-producing pathways, we assessed the expression and function of cyclooxygenase (COX) isoforms. A specific upregulation of COX-2 in the vascular endothelium and increased urinary excretion of prostaglandin E(2) were observed in the Eng(+/-) mice. Specific COX-2 inhibition with parecoxib transiently increased arterial pressure in Eng(+/-) but not in Eng(+/+) mice. Transfection of endoglin in L6E9 myoblasts, shown previously to stimulate eNOS expression, led to downregulation of COX-2 with no change in COX-1. In addition, COX-2 promoter activity and protein levels were inversely correlated with endoglin levels, in doxycyclin-inducible endothelial cells. Chronic NO synthesis inhibition with N(omega)-nitro-l-arginine methyl ester induced a marked increase in COX-2 only in the normal Eng(+/+) mice. N(omega)-nitro-l-arginine methyl ester also increased COX-2 expression and promoter activity in doxycyclin-inducible endoglin expressing endothelial cells, but not in control cells. The level of COX-2 expression following transforming growth factor-beta1 treatment was less in endoglin than in mock transfected L6E9 myoblasts and was higher in human endothelial cells silenced for endoglin expression. Our results indicate that endoglin is involved in the regulation of COX-2 activity. Furthermore, reduced endoglin levels and associated impaired NO production may be responsible, at least in part, for augmented COX-2 expression and activity in the Eng(+/-) mice."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.0000236755.98627.69"xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/author | "Bernabeu C."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/author | "Letarte M."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/author | "Prieto M."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/author | "Vary C.P."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/author | "Arevalo M."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/author | "Lopez-Novoa J.M."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/author | "Santibanez J.F."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/author | "Rodriguez-Barbero A."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/author | "Jerkic M."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/author | "Perez-Barriocanal F."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/author | "Rivas-Elena J.V."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/author | "Pericacho M."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/pages | "248-256"xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/title | "Endoglin regulates cyclooxygenase-2 expression and activity."xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/16840721 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16840721 |
| http://purl.uniprot.org/citations/16840721 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16840721 |
| http://purl.uniprot.org/uniprot/#_A0A087WPT2-mappedCitation-16840721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16840721 |
| http://purl.uniprot.org/uniprot/#_A8K2X4-mappedCitation-16840721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16840721 |
| http://purl.uniprot.org/uniprot/#_F7BZW0-mappedCitation-16840721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16840721 |