| http://purl.uniprot.org/citations/16842770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16842770 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously demonstrated that male mice deficient in the soluble adenylyl cyclase (sAC) are sterile and produce spermatozoa with deficits in progressive motility and are unable to fertilize zona-intact eggs. Here, analyses of sAC(-/-) spermatozoa provide additional insights into the functions linked to cAMP signaling. Adenylyl cyclase activity and cAMP content are greatly diminished in crude preparations of sAC(-/-) spermatozoa and are undetectable after sperm purification. HCO(3)(-) is unable to rapidly accelerate the flagellar beat or facilitate evoked Ca(2+) entry into sAC(-/-) spermatozoa. Moreover, the delayed HCO(3)(-)-dependent increases in protein tyrosine phosphorylation and hyperactivated motility, which occur late in capacitation of wild-type spermatozoa, do not develop in sAC(-/-) spermatozoa. However, sAC(-/-) sperm fertilize zona-free oocytes, indicating that gamete fusion does not require sAC. Although ATP levels are significantly reduced in sAC(-/-) sperm, cAMP-AM ester increases flagellar beat frequency, progressive motility, and alters the pattern of tyrosine phosphorylated proteins. These results indicate that sAC and cAMP coordinate cellular energy balance in wild-type sperm and that the ATP generating machinery is not operating normally in sAC(-/-) spermatozoa. These findings demonstrate that sAC plays a critical role in cAMP signaling in spermatozoa and that defective cAMP production prevents engagement of multiple components of capacitation resulting in male infertility."xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2006.05.038"xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/author | "Esposito G."xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/author | "Xie F."xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/author | "Gossen J.A."xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/author | "Garcia M.A."xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/author | "Conti M."xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/author | "Jaiswal B.S."xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/author | "van Duin M."xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/author | "Babcock D.F."xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/author | "Carlson A.E."xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/author | "Schuh S.M."xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/pages | "353-362"xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/title | "Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization."xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://purl.uniprot.org/core/volume | "296"xsd:string |
| http://purl.uniprot.org/citations/16842770 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16842770 |
| http://purl.uniprot.org/citations/16842770 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16842770 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXI1-mappedCitation-16842770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16842770 |
| http://purl.uniprot.org/uniprot/#_E9Q9T4-mappedCitation-16842770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16842770 |
| http://purl.uniprot.org/uniprot/#_B1PMG2-mappedCitation-16842770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16842770 |
| http://purl.uniprot.org/uniprot/#_M0QWB5-mappedCitation-16842770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16842770 |
| http://purl.uniprot.org/uniprot/#_Q8C0T9-mappedCitation-16842770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16842770 |