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http://purl.uniprot.org/citations/16847139http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16847139http://www.w3.org/2000/01/rdf-schema#comment"Phage P4 int gene encodes the integrase responsible for phage integration into and excision from the Escherichia coli chromosome. Here, the data showing that P4 int expression is regulated in a complex manner at different levels are presented. First of all, the Pint promoter is regulated negatively by both Int and Vis, the P4 excisionase. The N-terminal portion of Int appears to be sufficient for such a negative autoregulation, suggesting that the Int N terminus is implicated in DNA binding. Second, full-length transcripts covering the entire int gene could be detected only upon P4 infection, whereas in P4 lysogens only short 5'-end covering transcripts were detectable. On the other hand, transcripts covering the 5'-end of int were also very abundant upon infection. It thus appears that premature transcription termination and/or mRNA degradation play a role in Int-negative regulation both on the basal prophage transcription and upon infection. Finally, comparison between Pint-lacZ transcriptional and translational fusions suggests that Vis regulates Int expression post-transcriptionally. The findings that Vis is also an RNA-binding protein and that Int may be translated from two different start codons have implications on possible regulation models of Int expression."xsd:string
http://purl.uniprot.org/citations/16847139http://purl.org/dc/terms/identifier"doi:10.1099/vir.0.81875-0"xsd:string
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/author"Sala C."xsd:string
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/author"Deho G."xsd:string
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/author"Ghisotti D."xsd:string
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/author"Forti F."xsd:string
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/author"Piazzolla D."xsd:string
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/author"Cali S."xsd:string
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/author"Magnoni F."xsd:string
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/author"Spoldi E."xsd:string
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/name"J Gen Virol"xsd:string
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/pages"2423-2431"xsd:string
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/title"Expression of phage P4 integrase is regulated negatively by both Int and Vis."xsd:string
http://purl.uniprot.org/citations/16847139http://purl.uniprot.org/core/volume"87"xsd:string
http://purl.uniprot.org/citations/16847139http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16847139
http://purl.uniprot.org/citations/16847139http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16847139
http://purl.uniprot.org/uniprot/P08320#attribution-478230C712ED69B4A5D5A4C9A27D8136http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/16847139
http://purl.uniprot.org/uniprot/#_P08320-mappedCitation-16847139http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16847139
http://purl.uniprot.org/uniprot/#_P12552-mappedCitation-16847139http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16847139
http://purl.uniprot.org/uniprot/P12552http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16847139
http://purl.uniprot.org/uniprot/P08320http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16847139