| http://purl.uniprot.org/citations/16847321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16847321 | http://www.w3.org/2000/01/rdf-schema#comment | "The classical mechanism by which prolactin transduces its signal in mammary epithelial cells is by activation of cytosolic signal transducer and activator of transcription 5 (Stat5) via a plasma membrane-associated prolactin receptor-Janus kinase 2 (Jak2) complex. Here we describe an alternative pathway through which prolactin via Jak2 localized in the nucleus activates the transcription factor nuclear factor 1-C2 (NF1-C2). Previous reports have demonstrated a nuclear localization of Jak2, but the physiologic importance of nuclear Jak2 has not been clear. We demonstrate that nuclear Jak2 regulates the amount of active NF1-C2 through tyrosine phosphorylation and proteasomal degradation. Our data also demonstrate a link between prolactin and p53 as well as the milk gene carboxyl ester lipase through nuclear Jak2 and NF1-C2. Hence, we describe a novel pathway through which nuclear Jak2 is subject to regulation by prolactin in mammary epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/16847321 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.02095-05"xsd:string |
| http://purl.uniprot.org/citations/16847321 | http://purl.uniprot.org/core/author | "Nilsson J."xsd:string |
| http://purl.uniprot.org/citations/16847321 | http://purl.uniprot.org/core/author | "Bjursell G."xsd:string |
| http://purl.uniprot.org/citations/16847321 | http://purl.uniprot.org/core/author | "Kannius-Janson M."xsd:string |
| http://purl.uniprot.org/citations/16847321 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16847321 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16847321 | http://purl.uniprot.org/core/pages | "5663-5674"xsd:string |
| http://purl.uniprot.org/citations/16847321 | http://purl.uniprot.org/core/title | "Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/16847321 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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