| http://purl.uniprot.org/citations/16848785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16848785 | http://www.w3.org/2000/01/rdf-schema#comment | "Inositol plays a key role in dopamine, serotonin, noradrenaline and acetylcholine neurotransmission, and inositol treatment is reported to have beneficial effects in depression and anxiety. Therefore, a reduction in brain intracellular inositol levels could be a cause of some psychiatric disorders, such as depression or anxiety. To determine the behavioural consequences of inositol depletion, we studied the behaviour of sodium-dependent myo-inositol cotransporter-1 heterozygous knockout mice. In heterozygous mice, free inositol levels were reduced by 15% in the frontal cortex and by 25% in the hippocampus, but they did not differ from their wild-type littermates in cholinergic-mediated lithium-pilocarpine seizures, in the apomorphine-induced stereotypic climbing model of dopaminergic system function, in the Porsolt forced-swimming test model of depression, in amphetamine-induced hyperactivity, or in the elevated plus-maze model of anxiety. Reduction of brain inositol by more than 25% may be required to elicit neurobehavioural effects."xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1601-183x.2006.00253.x"xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://purl.uniprot.org/core/author | "Agam G."xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://purl.uniprot.org/core/author | "Belmaker R.H."xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://purl.uniprot.org/core/author | "Berry G.T."xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://purl.uniprot.org/core/author | "Buccafusca R."xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://purl.uniprot.org/core/author | "Johanson R.A."xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://purl.uniprot.org/core/author | "Bersudsky Y."xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://purl.uniprot.org/core/author | "Shaldubina A."xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/16848785 | http://purl.uniprot.org/core/name | "Genes Brain Behav"xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://purl.uniprot.org/core/pages | "253-259"xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://purl.uniprot.org/core/title | "Behavioural phenotyping of sodium-myo-inositol cotransporter heterozygous knockout mice with reduced brain inositol."xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/16848785 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16848785 |
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