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| http://purl.uniprot.org/citations/16849466 | http://www.w3.org/2000/01/rdf-schema#comment | "Differences in BCR signaling may govern outcomes as diverse as proliferation and cell death. We profiled BCR signaling kinetics in subsets of primary human B cells using flow cytometry. In the predominant population expressing IgM, BCR cross-linking led to a quick burst of Syk, ERK1/2, and p38 signaling. In contrast, IgG B cells sustained higher per-cell ERK1/2 phosphorylation over time. This dichotomy suggested a mechanism for dampening signals transmitted by IgM. Regulatory phosphatase activity in IgM B cells was BCR-mediated and initiated more slowly than kinase activity. This BCR-mediated phosphatase activity was sensitive to inhibition by H(2)O(2) and required to attenuate IgM BCR signaling. These results provide the first kinetic maps of BCR signaling in primary human B cell subsets and enable new studies of signaling in B cell disorders, such as autoimmunity and cancer."xsd:string |
| http://purl.uniprot.org/citations/16849466 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.3.1581"xsd:string |
| http://purl.uniprot.org/citations/16849466 | http://purl.uniprot.org/core/author | "Levy R."xsd:string |
| http://purl.uniprot.org/citations/16849466 | http://purl.uniprot.org/core/author | "Nolan G.P."xsd:string |
| http://purl.uniprot.org/citations/16849466 | http://purl.uniprot.org/core/author | "Czerwinski D.K."xsd:string |
| http://purl.uniprot.org/citations/16849466 | http://purl.uniprot.org/core/author | "Irish J.M."xsd:string |
| http://purl.uniprot.org/citations/16849466 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16849466 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16849466 | http://purl.uniprot.org/core/pages | "1581-1589"xsd:string |
| http://purl.uniprot.org/citations/16849466 | http://purl.uniprot.org/core/title | "Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry."xsd:string |
| http://purl.uniprot.org/citations/16849466 | http://purl.uniprot.org/core/volume | "177"xsd:string |
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