| http://purl.uniprot.org/citations/16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16849481 | http://www.w3.org/2000/01/rdf-schema#comment | "Induction of T cell responses following engagement of the Ag-specific TCR depends on TCR-initiated rearrangements of the cellular actin cytoskeleton and highly coordinated and tightly regulated interactions and of diverse intracellular signaling proteins. In this study, we show that filamin A (FLNa), an actin-binding and signal mediator scaffolding protein, is required for T cell activation. Following Ag stimulation, FLNa was recruited to the T cell-APC contact area, where it colocalized with protein kinase C-theta (PKCtheta). Depletion of FLNa by RNA interference did not affect TCR-induced early tyrosine phosphorylation or actin polymerization but, nevertheless, resulted in impaired IL-2 expression by human primary T cells and reduced activation of NF-kappaB, AP-1, and NFAT reporter genes in transfected T cells. TCR stimulation induced stable physical association of FLNa with PKCtheta. Furthermore, the TCR/CD28-induced membrane translocation of PKCtheta was inhibited in FLNa-depleted T cells. These results reveal novel role for FLNa in the TCR/CD28 signaling pathway leading to transcription factor activation and IL-2 production, and suggest that this role is mediated, in part, through the inducible interaction of FLNa with PKCtheta."xsd:string |
| http://purl.uniprot.org/citations/16849481 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.3.1721"xsd:string |
| http://purl.uniprot.org/citations/16849481 | http://purl.uniprot.org/core/author | "Hayashi K."xsd:string |
| http://purl.uniprot.org/citations/16849481 | http://purl.uniprot.org/core/author | "Altman A."xsd:string |
| http://purl.uniprot.org/citations/16849481 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16849481 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16849481 | http://purl.uniprot.org/core/pages | "1721-1728"xsd:string |
| http://purl.uniprot.org/citations/16849481 | http://purl.uniprot.org/core/title | "Filamin A is required for T cell activation mediated by protein kinase C-theta."xsd:string |
| http://purl.uniprot.org/citations/16849481 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/16849481 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16849481 |
| http://purl.uniprot.org/citations/16849481 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16849481 |
| http://purl.uniprot.org/uniprot/#_A0A075TSG1-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |
| http://purl.uniprot.org/uniprot/#_B4E2F9-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |
| http://purl.uniprot.org/uniprot/#_A6NDY9-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |
| http://purl.uniprot.org/uniprot/#_B4DTD5-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |
| http://purl.uniprot.org/uniprot/#_Q86TQ3-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |
| http://purl.uniprot.org/uniprot/#_Q04759-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |
| http://purl.uniprot.org/uniprot/#_P21333-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |
| http://purl.uniprot.org/uniprot/#_Q2VP91-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |
| http://purl.uniprot.org/uniprot/#_Q6NXF2-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |
| http://purl.uniprot.org/uniprot/#_Q96C61-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |
| http://purl.uniprot.org/uniprot/#_Q60FE5-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |
| http://purl.uniprot.org/uniprot/#_Q60FE6-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |
| http://purl.uniprot.org/uniprot/#_Q8TES4-mappedCitation-16849481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16849481 |