| http://purl.uniprot.org/citations/16854219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16854219 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundDevelopment of the enteric nervous system (ENS) requires interactions between migrating neural crest cells and the nascent gastrointestinal tract that are dependent upon genes expressed by both cell compartments. Hlx, a homeobox transcription factor gene that is expressed in mouse intestinal and hepatic mesenchyme, is required for normal embryonic growth of intestine and liver, and the Hlx-/-genotype is embryonic lethal. We hypothesized that Hlx is required for ENS development.ResultsEnteric neurons were identified in Hlx+/+ and Hlx-/-mouse embryos by immunostaining of embryo sections for the neural markers PGP9.5 and Phox2b, or by staining for beta-galactosidase in whole-mount embryos containing the dopamine beta-hydroxylase-nLacZ transgene. In Hlx+/+ embryos, neural crest cells/enteric neurons have moved from the stomach into the intestine by E10.5. By contrast, neural crest cells/enteric neurons remain largely restricted to the lateral stomach mesenchyme of Hlx-/-embryos, with only a few scattered neural crest cells/enteric neurons in the intestine between E10.5-16.5.ConclusionThe Hlx homeobox transcription factor is required for early aspects of ENS development."xsd:string |
| http://purl.uniprot.org/citations/16854219 | http://purl.org/dc/terms/identifier | "doi:10.1186/1471-213x-6-33"xsd:string |
| http://purl.uniprot.org/citations/16854219 | http://purl.uniprot.org/core/author | "Harvey R.P."xsd:string |
| http://purl.uniprot.org/citations/16854219 | http://purl.uniprot.org/core/author | "Bates M.D."xsd:string |
| http://purl.uniprot.org/citations/16854219 | http://purl.uniprot.org/core/author | "Kaul A."xsd:string |
| http://purl.uniprot.org/citations/16854219 | http://purl.uniprot.org/core/author | "Dunagan D.T."xsd:string |
| http://purl.uniprot.org/citations/16854219 | http://purl.uniprot.org/core/author | "Welch L.C."xsd:string |
| http://purl.uniprot.org/citations/16854219 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16854219 | http://purl.uniprot.org/core/name | "BMC Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/16854219 | http://purl.uniprot.org/core/pages | "33"xsd:string |
| http://purl.uniprot.org/citations/16854219 | http://purl.uniprot.org/core/title | "The Hlx homeobox transcription factor is required early in enteric nervous system development."xsd:string |
| http://purl.uniprot.org/citations/16854219 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/16854219 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16854219 |
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