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| http://purl.uniprot.org/citations/16854971 | http://www.w3.org/2000/01/rdf-schema#comment | "Epithelial morphogenesis requires cell movements and cell shape changes coordinated by modulation of the actin cytoskeleton. We identify a role for Echinoid (Ed), an immunoglobulin domain-containing cell-adhesion molecule, in the generation of a contractile actomyosin cable required for epithelial morphogenesis in both the Drosophila ovarian follicular epithelium and embryo. Analysis of ed mutant follicle cell clones indicates that the juxtaposition of wild-type and ed mutant cells is sufficient to trigger actomyosin cable formation. Moreover, in wild-type ovaries and embryos, specific epithelial domains lack detectable Ed, thus creating endogenous interfaces between cells with and without Ed; these interfaces display the same contractile characteristics as the ectopic Ed expression borders generated by ed mutant clones. In the ovary, such an interface lies between the two cell types of the dorsal appendage primordia. In the embryo, Ed is absent from the amnioserosa during dorsal closure, generating an Ed expression border with the lateral epidermis that coincides with the actomyosin cable present at this interface. In both cases, ed mutant epithelia exhibit loss of this contractile structure and subsequent defects in morphogenesis. We propose that local modulation of the cytoskeleton at Ed expression borders may represent a general mechanism for promoting epithelial morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/16854971 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.02492"xsd:string |
| http://purl.uniprot.org/citations/16854971 | http://purl.uniprot.org/core/author | "Nilson L.A."xsd:string |
| http://purl.uniprot.org/citations/16854971 | http://purl.uniprot.org/core/author | "Laplante C."xsd:string |
| http://purl.uniprot.org/citations/16854971 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16854971 | http://purl.uniprot.org/core/name | "Development"xsd:string |
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| http://purl.uniprot.org/citations/16854971 | http://purl.uniprot.org/core/title | "Differential expression of the adhesion molecule Echinoid drives epithelial morphogenesis in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/16854971 | http://purl.uniprot.org/core/volume | "133"xsd:string |
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