| http://purl.uniprot.org/citations/16854972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16854972 | http://www.w3.org/2000/01/rdf-schema#comment | "In Caenorhabditis elegans, EFL-1 (E2F), DPL-1 (DP) and LIN-35 (pRb) act coordinately in somatic tissues to inhibit ectopic cell division, probably by repressing the expression of target genes. EFL-1, DPL-1 and LIN-35 are also present in the germline, but do not always act together. Strong loss-of-function mutations in either efl-1 or dpl-1 cause defects in oogenesis that result in sterility, while lin-35 mutants are fertile with reduced broods. Microarray-based expression profiling of dissected gonads from efl-1, dpl-1 and lin-35 mutants reveals that EFL-1 and DPL-1 promote expression of an extensively overlapping set of target genes, consistent with the expectation that these two proteins function as a heterodimer. Regulatory regions upstream of many of these target genes have a canonical E2F-binding site, suggesting that their regulation by EFL-1/DPL-1 is direct. Many EFL-1/DPL-1 responsive genes encode proteins required for oogenesis and early embryogenesis, rather than cell cycle components. By contrast, LIN-35 appears to function primarily as a repressor of gene expression in the germline, and the genes that it acts on are for the most part distinct from those regulated by EFL-1 and/or DPL-1. Thus, in vivo, C. elegans E2F directly promotes oogenesis and embryogenesis through the activation of a tissue-specific transcriptional program that does not require LIN-35."xsd:string |
| http://purl.uniprot.org/citations/16854972 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.02490"xsd:string |
| http://purl.uniprot.org/citations/16854972 | http://purl.uniprot.org/core/author | "Chi W."xsd:string |
| http://purl.uniprot.org/citations/16854972 | http://purl.uniprot.org/core/author | "Reinke V."xsd:string |
| http://purl.uniprot.org/citations/16854972 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16854972 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/16854972 | http://purl.uniprot.org/core/pages | "3147-3157"xsd:string |
| http://purl.uniprot.org/citations/16854972 | http://purl.uniprot.org/core/title | "Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB)."xsd:string |
| http://purl.uniprot.org/citations/16854972 | http://purl.uniprot.org/core/volume | "133"xsd:string |
| http://purl.uniprot.org/citations/16854972 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16854972 |
| http://purl.uniprot.org/citations/16854972 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16854972 |
| http://purl.uniprot.org/uniprot/Q03345#attribution-494F4EE8FD45B0E3D29982A500002947 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16854972 |
| http://purl.uniprot.org/uniprot/P42170#attribution-2E018612AC1E27AA069693365E79A79A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16854972 |
| http://purl.uniprot.org/uniprot/#_A0A131MAQ8-mappedCitation-16854972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16854972 |
| http://purl.uniprot.org/uniprot/#_A0A131MAV3-mappedCitation-16854972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16854972 |
| http://purl.uniprot.org/uniprot/#_A0A131MBB1-mappedCitation-16854972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16854972 |
| http://purl.uniprot.org/uniprot/#_A0A131MC76-mappedCitation-16854972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16854972 |
| http://purl.uniprot.org/uniprot/#_A0A131MCL1-mappedCitation-16854972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16854972 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AWM6-mappedCitation-16854972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16854972 |
| http://purl.uniprot.org/uniprot/#_A0A061AD21-mappedCitation-16854972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16854972 |
| http://purl.uniprot.org/uniprot/#_A0A061AD43-mappedCitation-16854972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16854972 |
| http://purl.uniprot.org/uniprot/#_A0A061AEC4-mappedCitation-16854972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16854972 |
| http://purl.uniprot.org/uniprot/#_A0A061AJI9-mappedCitation-16854972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16854972 |
| http://purl.uniprot.org/uniprot/#_A0A0K3ATC0-mappedCitation-16854972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16854972 |