| http://purl.uniprot.org/citations/16856175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16856175 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblast growth factors (FGFs) are polypeptides that exert diverse biological effects on many cell types and tissues during embryogenesis and adulthood. In the adult brain, FGF-2 is primarily expressed by astrocytes and select groups of neurons. It has been shown that FGF-2 is neuroprotective and can stimulate proliferation of NSCs in neurogenic regions of the adult mammalian brain. Cellular responses to FGFs are mediated through membrane-spanning tyrosine kinase receptors in conjunction with low affinity binding to heparin sulfate proteoglycans. Four FGF receptors (FGFR1-4) have been cloned and characterized to date. In this study, we describe the anatomical distribution of FGFR-2 in young and aged rat brains. We demonstrate that the olfactory bulb, hippocampus, and cerebellum display the most robust FGFR-2 expression and observed age-related decrease in FGFR-2 levels in some but not all brain regions. In addition, we identified astrocytes as the primary source of FGFR-2 expression using immunofluorescence confocal microscopy. The astrocyte populations in the neurogenic areas, the subventricular zone (SVZ) and the subgranular zone (SGZ) of the dentate gyrus, express high levels of FGFR-2 protein, which points to its possible involvement in neurogenesis. We also explored the role of FGFR-2 in response to perforant pathway lesion and observed enhanced FGFR-2 expression by astrocytes surrounding the lesion. Thus, FGF-2 biological effects on astrocytes appear to be mediated through FGFR-2-dependent mechanisms, and this may provide an indirect route by which FGF-2 acts on neuronal populations."xsd:string |
| http://purl.uniprot.org/citations/16856175 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.21009"xsd:string |
| http://purl.uniprot.org/citations/16856175 | http://purl.uniprot.org/core/author | "Peterson D.A."xsd:string |
| http://purl.uniprot.org/citations/16856175 | http://purl.uniprot.org/core/author | "Chadashvili T."xsd:string |
| http://purl.uniprot.org/citations/16856175 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16856175 | http://purl.uniprot.org/core/name | "J Comp Neurol"xsd:string |
| http://purl.uniprot.org/citations/16856175 | http://purl.uniprot.org/core/pages | "1-15"xsd:string |
| http://purl.uniprot.org/citations/16856175 | http://purl.uniprot.org/core/title | "Cytoarchitecture of fibroblast growth factor receptor 2 (FGFR-2) immunoreactivity in astrocytes of neurogenic and non-neurogenic regions of the young adult and aged rat brain."xsd:string |
| http://purl.uniprot.org/citations/16856175 | http://purl.uniprot.org/core/volume | "498"xsd:string |
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