| http://purl.uniprot.org/citations/16857187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16857187 | http://www.w3.org/2000/01/rdf-schema#comment | "The syntrophins are a family of scaffolding proteins with multiple protein interaction domains that link signaling proteins to dystrophin family members. Each of the three most characterized syntrophins (alpha, beta1, beta2) contains a PDZ domain that binds a unique set of signaling proteins including kinases, ion and water channels, and neuronal nitric oxide synthase (nNOS). The PDZ domains of the gamma-syntrophins do not bind nNOS. In vitro pull-down assays show that the gamma-syntrophins can bind dystrophin but have unique preferences for the syntrophin binding sites of dystrophin family members. Despite their ability to bind dystrophin in vitro, neither gamma-syntrophin isoform co-localizes with dystrophin in skeletal muscle. Furthermore, gamma-syntrophins do not co-purify with dystrophin isolated from mouse tissue. These data suggest that the interaction of gamma-syntrophin with dystrophin is transient and potentially subject to regulatory mechanisms. gamma1-Syntrophin is highly expressed in brain and is specifically localized in hippocampal pyramidal neurons, Purkinje neurons in cerebellum, and cortical neurons. gamma2-Syntrophin is expressed in many tissues including skeletal muscle where it is found only in the subsynaptic space beneath the neuromuscular junction. In both neurons and muscle, gamma-syntrophin isoforms localize to the endoplasmic reticulum where they may form a scaffold for signaling and trafficking."xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2006.06.019"xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://purl.uniprot.org/core/author | "Yoo J."xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://purl.uniprot.org/core/author | "Adams M.E."xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://purl.uniprot.org/core/author | "Froehner S.C."xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://purl.uniprot.org/core/author | "Albrecht D.E."xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://purl.uniprot.org/core/author | "Alessi A."xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://purl.uniprot.org/core/author | "Percival J.M."xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://purl.uniprot.org/core/author | "Bragg A.D."xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16857187 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://purl.uniprot.org/core/pages | "3084-3095"xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://purl.uniprot.org/core/title | "gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins."xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://purl.uniprot.org/core/volume | "312"xsd:string |
| http://purl.uniprot.org/citations/16857187 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16857187 |
| http://purl.uniprot.org/citations/16857187 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16857187 |
| http://purl.uniprot.org/uniprot/#_A0A023ZT56-mappedCitation-16857187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857187 |
| http://purl.uniprot.org/uniprot/#_A0A023ZTV5-mappedCitation-16857187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857187 |
| http://purl.uniprot.org/uniprot/#_E9Q6R7-mappedCitation-16857187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857187 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1NN66-mappedCitation-16857187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857187 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1PRS2-mappedCitation-16857187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857187 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1PRS4-mappedCitation-16857187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857187 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1PRS6-mappedCitation-16857187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857187 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1PRS9-mappedCitation-16857187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857187 |