| http://purl.uniprot.org/citations/16857194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16857194 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased plasminogen activator inhibitor-1 (PAI-1) activity is associated with greater risk of myocardial infarction. PAI-1 expression is regulated by a 4G/5G promoter polymorphism. The 4G allele is associated with higher PAI-levels and greater circadian variation. Here we show that clock protein heterodimers BMAL/CLOCK cause greater activation (approximately 2-fold, P<0.05) of the 4G allele. Site-directed mutagenesis studies suggest that clock genes act on two canonical E-boxes to regulate PAI-1 promoter activity. These results identify a potential novel mechanism whereby allele-specific clock genes - mediated modulation of PAI-1 expression may contribute to circadian variation in cardiac risk."xsd:string |
| http://purl.uniprot.org/citations/16857194 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2006.07.014"xsd:string |
| http://purl.uniprot.org/citations/16857194 | http://purl.uniprot.org/core/author | "Chong N.W."xsd:string |
| http://purl.uniprot.org/citations/16857194 | http://purl.uniprot.org/core/author | "Samani N.J."xsd:string |
| http://purl.uniprot.org/citations/16857194 | http://purl.uniprot.org/core/author | "Chan D."xsd:string |
| http://purl.uniprot.org/citations/16857194 | http://purl.uniprot.org/core/author | "Codd V."xsd:string |
| http://purl.uniprot.org/citations/16857194 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16857194 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/16857194 | http://purl.uniprot.org/core/pages | "4469-4472"xsd:string |
| http://purl.uniprot.org/citations/16857194 | http://purl.uniprot.org/core/title | "Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference."xsd:string |
| http://purl.uniprot.org/citations/16857194 | http://purl.uniprot.org/core/volume | "580"xsd:string |
| http://purl.uniprot.org/citations/16857194 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16857194 |
| http://purl.uniprot.org/citations/16857194 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16857194 |
| http://purl.uniprot.org/uniprot/#_O00327-mappedCitation-16857194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857194 |
| http://purl.uniprot.org/uniprot/#_O15516-mappedCitation-16857194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857194 |
| http://purl.uniprot.org/uniprot/#_P05121-mappedCitation-16857194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857194 |
| http://purl.uniprot.org/uniprot/#_Q99743-mappedCitation-16857194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857194 |
| http://purl.uniprot.org/uniprot/#_Q8WYA1-mappedCitation-16857194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16857194 |
| http://purl.uniprot.org/uniprot/Q99743 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16857194 |
| http://purl.uniprot.org/uniprot/Q8WYA1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16857194 |
| http://purl.uniprot.org/uniprot/O15516 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16857194 |
| http://purl.uniprot.org/uniprot/O00327 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16857194 |
| http://purl.uniprot.org/uniprot/P05121 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16857194 |