| http://purl.uniprot.org/citations/16858678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16858678 | http://www.w3.org/2000/01/rdf-schema#comment | "Multiple investigations of the effects of peroxisome proliferator-activated receptor gamma (PPARgamma) ligands on colon cancer have produced contradictory results. While some studies demonstrated increased numbers of colonic polyps in Apc(Min/+) mice treated with various thiazolidinedione (TZD) PPARgamma ligands, others reported amelioration of tumor multiplicity and progression in both Apc(Min/+) mice and in mice with chemically-induced colon cancer. Here, we addressed the role of PPARgamma in murine intestinal tumorigenesis using gene knockout methodology. We found that either heterozygous or homozygous intestinal-specific PPARgamma deficiency enhanced the number of Apc(Min/+) tumors in both the small intestine and colon, especially in the colon, where PPARgamma deficiency also modulated tumor incidence. Gender significantly affected tumor multiplicity independent of PPARgamma genotype. Female Apc(Min/+) mice developed more tumors in the small intestine and more tumors overall, whereas male Apc(Min/+) mice developed more tumors in the colon. Nevertheless, intestinal PPARgamma deficiency enhanced tumorigenesis irrespective of gender. Our results suggest that PPARgamma functions as a tumor resistance factor in the mouse intestine and warrant further investigation of the PPARgamma-dependent and independent actions of TZDs in cancer."xsd:string |
| http://purl.uniprot.org/citations/16858678 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.22115"xsd:string |
| http://purl.uniprot.org/citations/16858678 | http://purl.uniprot.org/core/author | "Barak Y."xsd:string |
| http://purl.uniprot.org/citations/16858678 | http://purl.uniprot.org/core/author | "Cormier R.T."xsd:string |
| http://purl.uniprot.org/citations/16858678 | http://purl.uniprot.org/core/author | "Matise I."xsd:string |
| http://purl.uniprot.org/citations/16858678 | http://purl.uniprot.org/core/author | "McAlpine C.A."xsd:string |
| http://purl.uniprot.org/citations/16858678 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16858678 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/16858678 | http://purl.uniprot.org/core/pages | "2339-2346"xsd:string |
| http://purl.uniprot.org/citations/16858678 | http://purl.uniprot.org/core/title | "Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice."xsd:string |
| http://purl.uniprot.org/citations/16858678 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/16858678 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16858678 |
| http://purl.uniprot.org/citations/16858678 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16858678 |
| http://purl.uniprot.org/uniprot/#_D0EPX6-mappedCitation-16858678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16858678 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SV67-mappedCitation-16858678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16858678 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVF8-mappedCitation-16858678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16858678 |
| http://purl.uniprot.org/uniprot/#_A0N0C8-mappedCitation-16858678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16858678 |
| http://purl.uniprot.org/uniprot/#_A0N0D0-mappedCitation-16858678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16858678 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-16858678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16858678 |
| http://purl.uniprot.org/uniprot/#_E9QLQ9-mappedCitation-16858678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16858678 |
| http://purl.uniprot.org/uniprot/#_F6Z405-mappedCitation-16858678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16858678 |
| http://purl.uniprot.org/uniprot/#_P70382-mappedCitation-16858678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16858678 |
| http://purl.uniprot.org/uniprot/#_D0EPX7-mappedCitation-16858678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16858678 |
| http://purl.uniprot.org/uniprot/#_D0EPX9-mappedCitation-16858678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16858678 |