| http://purl.uniprot.org/citations/16860373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16860373 | http://www.w3.org/2000/01/rdf-schema#comment | "14-3-3 proteins are evolutionarily conserved and ubiquitous proteins that function in a wide variety of biological processes. Here we define a new role for C. elegans 14-3-3 proteins in life span regulation. We identify two C. elegans 14-3-3 proteins as interacting proteins of a major life span regulator, the C. elegans SIR2 ortholog, SIR-2.1. Similar to sir-2.1, we find that overexpression of either 14-3-3 protein (PAR-5 or FTT-2) extends life span and that this is dependent on DAF-16, a forkhead transcription factor (FOXO), another important life span regulator in the insulin/IGF-1 signaling pathway. Furthermore, we show that both 14-3-3 proteins are co-expressed with DAF-16 and SIR-2.1 in the tissues critical for life span regulation. Finally, we show that DAF-16/FOXO also physically interacts with the 14-3-3 proteins. These results suggest that C. elegans 14-3-3 proteins can regulate longevity by cooperating with both SIR-2.1 and DAF-16/FOXO."xsd:string |
| http://purl.uniprot.org/citations/16860373 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mad.2006.05.005"xsd:string |
| http://purl.uniprot.org/citations/16860373 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/16860373 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/16860373 | http://purl.uniprot.org/core/author | "Tissenbaum H.A."xsd:string |
| http://purl.uniprot.org/citations/16860373 | http://purl.uniprot.org/core/author | "Walhout A.J."xsd:string |
| http://purl.uniprot.org/citations/16860373 | http://purl.uniprot.org/core/author | "Oh S.W."xsd:string |
| http://purl.uniprot.org/citations/16860373 | http://purl.uniprot.org/core/author | "Deplancke B."xsd:string |
| http://purl.uniprot.org/citations/16860373 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16860373 | http://purl.uniprot.org/core/name | "Mech Ageing Dev"xsd:string |
| http://purl.uniprot.org/citations/16860373 | http://purl.uniprot.org/core/pages | "741-747"xsd:string |
| http://purl.uniprot.org/citations/16860373 | http://purl.uniprot.org/core/title | "C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO."xsd:string |
| http://purl.uniprot.org/citations/16860373 | http://purl.uniprot.org/core/volume | "127"xsd:string |
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| http://purl.uniprot.org/citations/16860373 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16860373 |
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