| http://purl.uniprot.org/citations/16860759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16860759 | http://www.w3.org/2000/01/rdf-schema#comment | "The Tec family tyrosine kinases, Itk and Rlk, are expressed in thymocytes and peripheral T cells and regulate thresholds of T cell receptor signaling. Yet little is known about the specific role of Itk- and Rlk-dependent signals in CD8(+) T cell maturation. We show here that Itk(-/-) and Rlk(-/-)Itk(-/-) mice were nearly devoid of conventional CD8(+) T cells and, instead, contained a large population of CD8(+) T cells that bear striking similarity to lineages of innate lymphocytes. Itk(-/-) and Rlk(-/-)Itk(-/-) CD8(+) thymocytes and T cells were CD44(hi), CD122(+), and NK1.1(+); were able to produce interferon-gamma directly ex vivo; and were dependent on interleukin-15. Itk(-/-) and Rlk(-/-)Itk(-/-) CD8(+) thymocytes expressed abundant transcripts for the T box transcription factor, eomesodermin, correlating with their phenotype and function. These data indicate a critical role for Itk and Rlk in conventional CD8(+) T cell development in the thymus."xsd:string |
| http://purl.uniprot.org/citations/16860759 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2006.05.012"xsd:string |
| http://purl.uniprot.org/citations/16860759 | http://purl.uniprot.org/core/author | "Yin C.C."xsd:string |
| http://purl.uniprot.org/citations/16860759 | http://purl.uniprot.org/core/author | "Berg L.J."xsd:string |
| http://purl.uniprot.org/citations/16860759 | http://purl.uniprot.org/core/author | "Reiner S.L."xsd:string |
| http://purl.uniprot.org/citations/16860759 | http://purl.uniprot.org/core/author | "Felices M."xsd:string |
| http://purl.uniprot.org/citations/16860759 | http://purl.uniprot.org/core/author | "Lucas J.A."xsd:string |
| http://purl.uniprot.org/citations/16860759 | http://purl.uniprot.org/core/author | "Atherly L.O."xsd:string |
| http://purl.uniprot.org/citations/16860759 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16860759 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/16860759 | http://purl.uniprot.org/core/pages | "79-91"xsd:string |
| http://purl.uniprot.org/citations/16860759 | http://purl.uniprot.org/core/title | "The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells."xsd:string |
| http://purl.uniprot.org/citations/16860759 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16860759 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16860759 |
| http://purl.uniprot.org/citations/16860759 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16860759 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JG94-mappedCitation-16860759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16860759 |
| http://purl.uniprot.org/uniprot/#_Q0VBP6-mappedCitation-16860759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16860759 |
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| http://purl.uniprot.org/uniprot/#_A1A560-mappedCitation-16860759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16860759 |
| http://purl.uniprot.org/uniprot/#_P42682-mappedCitation-16860759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16860759 |
| http://purl.uniprot.org/uniprot/#_Q03526-mappedCitation-16860759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16860759 |
| http://purl.uniprot.org/uniprot/#_Q1AHQ6-mappedCitation-16860759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16860759 |