| http://purl.uniprot.org/citations/16860760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16860760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16860760 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations affecting the Tec kinases Itk and Rlk decrease T cell receptor-induced Ca(2+) mobilization and Erk kinase activation and impair both positive and negative thymic selection. Itk(-/-) and Rlk(-/-)Itk(-/-) mice also have decreased CD4:8 T cell ratios, suggestive of altered CD4:8 lineage commitment. Nonetheless, we find that CD8 single-positive (SP) thymocytes and peripheral CD8(+) T cells in these mice do not resemble conventional CD8(+) T cells. Instead, these cells express memory markers, rapidly produce interferon-gamma, and can be selected on hematopoietically derived cells, similar to MHC class Ib-restricted "innate-type" lymphocytes. Itk deficiency also greatly increases the number of cells selected by MHC class Ib. Expression of a hypersensitive Erk2 mutant partially corrects the CD8(+) T cell phenotypes in Itk(-/-) mice, arguing that altered signaling permits development of this innate-type CD8(+) cell population. Our results suggest that Tec kinases differentially regulate development of conventional versus nonconventional lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2006.05.011"xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2006.05.011"xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Schwartzberg P.L."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Schwartzberg P.L."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Fowlkes B.J."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Fowlkes B.J."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Hedrick S.M."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Hedrick S.M."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Horai R."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Horai R."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Broussard C."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Broussard C."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Chetana M."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Chetana M."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Fleischacker C."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Fleischacker C."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Sharp L.L."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Sharp L.L."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Venegas A.M."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/author | "Venegas A.M."xsd:string |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16860760 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |