| http://purl.uniprot.org/citations/16864657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16864657 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemoattractants like f-Met-Leu-Phe (fMLP) induce neutrophils to polarize by triggering divergent signals that promote the formation of protrusive filamentous actin (F-actin; frontness) and RhoA-dependent actomyosin contraction (backness). Frontness locally inhibits backness and vice versa. In neutrophil-like HL60 cells, blocking phosphatidylinositol-3,4,5-tris-phosphate (PIP3) accumulation with selective inhibitors of PIP3 synthesis completely prevents fMLP from activating a PIP3-dependent kinase and Cdc42 but not from stimulating F-actin accumulation. PIP3-deficient cells show reduced fMLP-dependent Rac activity and unstable pseudopods, which is consistent with the established role of PIP3 as a mediator of positive feedback pathways that augment Rac activation at the front. Surprisingly, such cells also show reduced RhoA activation and RhoA-dependent contraction at the trailing edge, leading to the formation of multiple lateral pseudopods. Cdc42 mediates PIP3's positive effect on RhoA activity. Thus, PIP3 and Cdc42 maintain stable polarity with a single front and a single back not only by strengthening pseudopods but also, at longer range, by promoting RhoA-dependent actomyosin contraction at the trailing edge."xsd:string |
| http://purl.uniprot.org/citations/16864657 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200604113"xsd:string |
| http://purl.uniprot.org/citations/16864657 | http://purl.uniprot.org/core/author | "Shokat K.M."xsd:string |
| http://purl.uniprot.org/citations/16864657 | http://purl.uniprot.org/core/author | "Wong K."xsd:string |
| http://purl.uniprot.org/citations/16864657 | http://purl.uniprot.org/core/author | "Bourne H.R."xsd:string |
| http://purl.uniprot.org/citations/16864657 | http://purl.uniprot.org/core/author | "Knight Z.A."xsd:string |
| http://purl.uniprot.org/citations/16864657 | http://purl.uniprot.org/core/author | "Hahn K.M."xsd:string |
| http://purl.uniprot.org/citations/16864657 | http://purl.uniprot.org/core/author | "Govaerts C."xsd:string |
| http://purl.uniprot.org/citations/16864657 | http://purl.uniprot.org/core/author | "Van Keymeulen A."xsd:string |
| http://purl.uniprot.org/citations/16864657 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16864657 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16864657 | http://purl.uniprot.org/core/pages | "437-445"xsd:string |
| http://purl.uniprot.org/citations/16864657 | http://purl.uniprot.org/core/title | "To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front."xsd:string |
| http://purl.uniprot.org/citations/16864657 | http://purl.uniprot.org/core/volume | "174"xsd:string |
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