DESCRIBE <http://purl.uniprot.org/citations/16865725>

Subject	Predicate	Object
http://purl.uniprot.org/citations/16865725	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16865725	http://www.w3.org/2000/01/rdf-schema#comment	" Background Inhibition of clusterin expression has been shown to enhance the sensitivity of prostate cancer cells to chemo and hormone therapy. Clusterin antisense oligonucleotides (ASOs) are currently in phase II human clinical trials for treatment of hormone refractory prostate cancer. However, the role of clusterin in androgen-regulated involution and regeneration of the normal prostate gland has not been established. Methods Prostate involution and regeneration was examined in clusterin-deficient mice undergoing up to three cycles of androgen withdrawal and restoration. Results Surprisingly, clusterin deficiency did not affect the apoptotic index, and the temporal biochemical and morphological changes associated with involution and regeneration of the normal adult prostate following multiple rounds of androgen withdrawal and replacement. Conclusion Clusterin is not critical for normal prostate development or androgen-regulated involution and regrowth of the mouse prostate gland, suggesting that clusterin may have distinct functions in malignant versus normal prostatic epithelial cells."xsd:string
http://purl.uniprot.org/citations/16865725	http://purl.org/dc/terms/identifier	"doi:10.1002/pros.20461"xsd:string
http://purl.uniprot.org/citations/16865725	http://purl.uniprot.org/core/author	"Fink D."xsd:string
http://purl.uniprot.org/citations/16865725	http://purl.uniprot.org/core/author	"Fazli L."xsd:string
http://purl.uniprot.org/citations/16865725	http://purl.uniprot.org/core/author	"Gleave M.E."xsd:string
http://purl.uniprot.org/citations/16865725	http://purl.uniprot.org/core/author	"Aronow B."xsd:string
http://purl.uniprot.org/citations/16865725	http://purl.uniprot.org/core/author	"Ong C.J."xsd:string
http://purl.uniprot.org/citations/16865725	http://purl.uniprot.org/core/date	"2006"xsd:gYear
http://purl.uniprot.org/citations/16865725	http://purl.uniprot.org/core/name	"Prostate"xsd:string
http://purl.uniprot.org/citations/16865725	http://purl.uniprot.org/core/pages	"1445-1454"xsd:string
http://purl.uniprot.org/citations/16865725	http://purl.uniprot.org/core/title	"Clusterin is not essential for androgen-regulated involution and regeneration of the normal mouse prostate."xsd:string
http://purl.uniprot.org/citations/16865725	http://purl.uniprot.org/core/volume	"66"xsd:string
http://purl.uniprot.org/citations/16865725	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/16865725
http://purl.uniprot.org/citations/16865725	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/16865725
http://purl.uniprot.org/uniprot/#_Q06890-mappedCitation-16865725	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16865725
http://purl.uniprot.org/uniprot/#_Q3V245-mappedCitation-16865725	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16865725
http://purl.uniprot.org/uniprot/#_Q549A5-mappedCitation-16865725	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16865725
http://purl.uniprot.org/uniprot/#_Q9JK98-mappedCitation-16865725	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16865725
http://purl.uniprot.org/uniprot/Q3V245	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16865725
http://purl.uniprot.org/uniprot/Q06890	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16865725
http://purl.uniprot.org/uniprot/Q549A5	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16865725
http://purl.uniprot.org/uniprot/Q9JK98	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16865725