| http://purl.uniprot.org/citations/16870134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16870134 | http://www.w3.org/2000/01/rdf-schema#comment | "SNAP-25 is a synaptosomal protein of 25 kDa, a key component of synaptic vesicle-docking/fusion machinery, and plays a critical role in exocytosis and neurotransmitter release. We previously reported that SNAP-25 in the hippocampal CA1 region is involved in consolidation of contextual fear memory and water-maze spatial memory (Hou et al. European J Neuroscience, 20: 1593-1603, 2004). SNAP-25 is expressed not only in the CA1 region, but also in the CA3 region, and the SNAP-25 mRNA level in the CA3 region is higher than in the CA1 region. Here, we provide evidence that SNAP-25 in the CA3 region is also involved in learning/memory. Intra-CA3 infusion of SNAP-25 antisense oligonucleotide impaired both long-term contextual fear memory and water-maze spatial memory, with short-term memory intact. Furthermore, the SNAP-25 antisense oligonucleotide suppressed the long-term potentiation (LTP) of field excitatory post-synaptic potential (fEPSP) in the mossy-fiber pathway (DG-CA3 pathway), with no effect on paired-pulse facilitation of the fEPSP. These results are consistent with the notion that SNAP-25 in the hippocampal CA3 region is required for long-term memory formation."xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.06.184"xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/author | "Gao X."xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/author | "Lu Q."xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/author | "Zhang X.H."xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/author | "Zhao G.P."xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/author | "Li B.M."xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/author | "Jin M.L."xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/author | "Hou Q.L."xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/author | "Jing N.H."xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/author | "Tu Y.Y."xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/pages | "955-962"xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/title | "SNAP-25 in hippocampal CA3 region is required for long-term memory formation."xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://purl.uniprot.org/core/volume | "347"xsd:string |
| http://purl.uniprot.org/citations/16870134 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16870134 |
| http://purl.uniprot.org/citations/16870134 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16870134 |
| http://purl.uniprot.org/uniprot/P60881#attribution-0C66A7ACD486C0E0A82AF8ABEFB36671 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16870134 |
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| http://purl.uniprot.org/uniprot/#_D4A5W9-mappedCitation-16870134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16870134 |
| http://purl.uniprot.org/uniprot/#_F8WG75-mappedCitation-16870134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16870134 |
| http://purl.uniprot.org/uniprot/#_Q2XTA5-mappedCitation-16870134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16870134 |