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| http://purl.uniprot.org/citations/16870704 | http://www.w3.org/2000/01/rdf-schema#comment | "Fodrin or nonerythroid spectrin is an abundant component of the cortical cytoskeletal network in rat adipocytes. Fodrin has a highly punctate distribution in resting cells, and insulin causes a dramatic remodeling of fodrin to a more diffuse pattern. Insulin-mediated remodeling of actin occurs to a lesser extent than does that of fodrin. We show that fodrin interacts with the t-soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) syntaxin 4, and this interaction is increased by insulin stimulation and decreased by prior latrunculin A treatment. Latrunculin A disrupts all actin filaments, inhibits glucose transporter 4 (GLUT4) translocation, and causes fodrin to partially redistribute from the plasma membrane to the cytosol. In contrast, cytochalasin D disrupts only the short actin filament signal, and cytochalasin D neither inhibits GLUT4 translocation nor fodrin redistribution in adipocytes. Together, our data suggest that insulin induces remodeling of the fodrin-actin network, which is required for the fusion of GLUT4 storage vesicles with the plasma membrane by permitting their access to the t-SNARE syntaxin 4."xsd:string |
| http://purl.uniprot.org/citations/16870704 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e06-04-0278"xsd:string |
| http://purl.uniprot.org/citations/16870704 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/16870704 | http://purl.uniprot.org/core/author | "Jedrychowski M.P."xsd:string |
| http://purl.uniprot.org/citations/16870704 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/16870704 | http://purl.uniprot.org/core/author | "Pilch P.F."xsd:string |
| http://purl.uniprot.org/citations/16870704 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16870704 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/16870704 | http://purl.uniprot.org/core/pages | "4249-4256"xsd:string |
| http://purl.uniprot.org/citations/16870704 | http://purl.uniprot.org/core/title | "Role of insulin-dependent cortical fodrin/spectrin remodeling in glucose transporter 4 translocation in rat adipocytes."xsd:string |
| http://purl.uniprot.org/citations/16870704 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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