| http://purl.uniprot.org/citations/16872604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16872604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16872604 | http://www.w3.org/2000/01/rdf-schema#comment | "ISG15, an interferon-upregulated ubiquitin-like protein, is covalently conjugated to various cellular proteins (ISGylation). In this study, we found that protein phosphatase 2Cbeta (PP2Cbeta), which functions in the nuclear factor kappaB (NF-kappaB) pathway via dephosphorylation of TGF-beta-activated kinase, was ISGylated, and analysis by NF-kappaB luciferase reporter assay revealed that PP2Cbeta activity was suppressed by co-expression of ISG15, UBE1L, and UbcH8. We determined the ISGylation sites of PP2Cbeta and constructed its ISGylation-resistant mutant. In contrast to the wild type, this mutant suppressed the NF-kappaB pathway even in the presence of ISG15, UBE1L, and UbcH8. Thus, we propose that ISGylation negatively regulates PP2Cbeta activity."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2006.07.032"xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2006.07.032"xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/author | "Takeuchi T."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/author | "Takeuchi T."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/author | "Tamura S."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/author | "Tamura S."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/author | "Yokosawa H."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/author | "Yokosawa H."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/pages | "4521-4526"xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/pages | "4521-4526"xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/title | "Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/title | "Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation."xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/volume | "580"xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://purl.uniprot.org/core/volume | "580"xsd:string |
| http://purl.uniprot.org/citations/16872604 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16872604 |
| http://purl.uniprot.org/citations/16872604 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16872604 |