| http://purl.uniprot.org/citations/16873060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16873060 | http://www.w3.org/2000/01/rdf-schema#comment | "The PML tumor suppressor controls key pathways for growth suppression, induction of apoptosis, and cellular senescence. PML loss occurs frequently in human tumors through unknown posttranslational mechanisms. Casein kinase 2 (CK2) is oncogenic and frequently upregulated in human tumors. Here we show that CK2 regulates PML protein levels by promoting its ubiquitin-mediated degradation dependent on direct phosphorylation at Ser517. Consequently, PML mutants that are resistant to CK2 phosphorylation display increased tumor-suppressive functions. In a faithful mouse model of lung cancer, we demonstrate that Pml inactivation leads to increased tumorigenesis. Furthermore, CK2 pharmacological inhibition enhances the PML tumor-suppressive property in vivo. Importantly, we found an inverse correlation between CK2 kinase activity and PML protein levels in human lung cancer-derived cell lines and primary specimens. These data identify a key posttranslational mechanism that controls PML protein levels and provide therapeutic means toward PML restoration through CK2 inhibition."xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.05.041"xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/author | "Singh B."xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/author | "Tempst P."xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/author | "Erdjument-Bromage H."xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/author | "Pandolfi P.P."xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/author | "Teruya-Feldstein J."xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/author | "Scaglioni P.P."xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/author | "Yung T.M."xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/author | "Cai L.F."xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/author | "Kaufman A.J."xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/pages | "269-283"xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/title | "A CK2-dependent mechanism for degradation of the PML tumor suppressor."xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/16873060 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16873060 |
| http://purl.uniprot.org/citations/16873060 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16873060 |
| http://purl.uniprot.org/uniprot/#_A0A068EW80-mappedCitation-16873060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16873060 |
| http://purl.uniprot.org/uniprot/#_D3YXR5-mappedCitation-16873060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16873060 |
| http://purl.uniprot.org/uniprot/#_F6XUT1-mappedCitation-16873060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16873060 |
| http://purl.uniprot.org/uniprot/#_D3Z2V0-mappedCitation-16873060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16873060 |
| http://purl.uniprot.org/uniprot/#_D3Z3A6-mappedCitation-16873060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16873060 |
| http://purl.uniprot.org/uniprot/#_D6RII9-mappedCitation-16873060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16873060 |