| http://purl.uniprot.org/citations/16873269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16873269 | http://www.w3.org/2000/01/rdf-schema#comment | "The human herpesvirus Epstein-Barr virus (EBV) establishes latency and promotes the long-term survival of its host B cell by targeting the molecular machinery controlling cell fate decisions. The cellular antiapoptotic bfl-1 gene confers protection from apoptosis under conditions of growth factor deprivation when expressed ectopically in an EBV-negative Burkitt's lymphoma-derived cell line (B. D'Souza, M. Rowe, and D. Walls, J. Virol. 74:6652-6658, 2000), and the EBV latent membrane protein 1 (LMP1) and its cellular functional homologue CD40 can both drive bfl-1 via an NF-kappaB-dependent enhancer element in the bfl-1 promoter (B. N. D'Souza, L. C. Edelstein, P. M. Pegman, S. M. Smith, S. T. Loughran, A. Clarke, A. Mehl, M. Rowe, C. Gélinas, and D. Walls, J. Virol. 78:1800-1816, 2004). Here we show that the EBV nuclear antigen 2 (EBNA2) also upregulates bfl-1. EBNA2 trans-activation of bfl-1 requires CBF1 (or RBP-J kappa), a nuclear component of the Notch signaling pathway, and there is an essential role for a core consensus CBF1-binding site on the bfl-1 promoter. trans-activation is dependent on the EBNA2-CBF1 interaction, is modulated by other EBV gene products known to interact with the CBF1 corepressor complex, and does not involve activation of NF-kappaB. bfl-1 expression is induced and maintained at high levels by the EBV growth program in a lymphoblastoid cell line, and withdrawal of either EBNA2 or LMP1 does not lead to a reduction in bfl-1 mRNA levels in this context, whereas the simultaneous loss of both EBV proteins results in a major decrease in bfl-1 expression. These findings are relevant to our understanding of EBV persistence, its role in malignant disease, and the B-cell developmental process."xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.00278-06"xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/author | "Smith S.M."xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/author | "Maier S."xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/author | "Kempkes B."xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/author | "Walls D."xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/author | "Gelinas C."xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/author | "Simmons M.J."xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/author | "Cahill P.A."xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/author | "D'Souza B.N."xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/author | "Loughran S.T."xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/author | "Pegman P.M."xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/pages | "8133-8144"xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/title | "Epstein-Barr virus nuclear antigen 2 trans-activates the cellular antiapoptotic bfl-1 gene by a CBF1/RBPJ kappa-dependent pathway."xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://purl.uniprot.org/core/volume | "80"xsd:string |
| http://purl.uniprot.org/citations/16873269 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16873269 |
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| http://purl.uniprot.org/uniprot/#_Q06330-mappedCitation-16873269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16873269 |
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