| http://purl.uniprot.org/citations/16873534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16873534 | http://www.w3.org/2000/01/rdf-schema#comment | "Puberty is a fundamental developmental process experienced by all reproductively competent adults, yet the specific factors that regulate variation in its timing remain elusive. Using a new approach to identifying these factors, we have performed a survey among a panel of chromosome substitution strains (for inbred strains C57BL/6J and A/J) followed by linkage analysis to map a quantitative trait locus (QTL) on the distal end of chromosome 6 that regulates pubertal timing (as assessed by vaginal opening) in mice. The location of the QTL was then refined to a region between marker D6MIT59 and the end of the chromosome by generating and phenotyping a panel of 12 congenic strains, each with a unique and overlapping homozygous segment of the A/J chromosome on an otherwise uniform C57BL/6J genomic background. Additional characterization of the QTL indicated that the effects of the responsible gene(s) are gender specific and inherited in a codominant manner without parent-of-origin effects. These findings represent an important advancement toward identification of novel factors that regulate maturation of the hypothalamic-pituitary-gonadal axis and determine the timing of puberty."xsd:string |
| http://purl.uniprot.org/citations/16873534 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2006-0745"xsd:string |
| http://purl.uniprot.org/citations/16873534 | http://purl.uniprot.org/core/author | "Burrage L.C."xsd:string |
| http://purl.uniprot.org/citations/16873534 | http://purl.uniprot.org/core/author | "Nadeau J.H."xsd:string |
| http://purl.uniprot.org/citations/16873534 | http://purl.uniprot.org/core/author | "Hodges C.A."xsd:string |
| http://purl.uniprot.org/citations/16873534 | http://purl.uniprot.org/core/author | "Palmert M.R."xsd:string |
| http://purl.uniprot.org/citations/16873534 | http://purl.uniprot.org/core/author | "Nathan B.M."xsd:string |
| http://purl.uniprot.org/citations/16873534 | http://purl.uniprot.org/core/author | "Supelak P.J."xsd:string |
| http://purl.uniprot.org/citations/16873534 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16873534 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/16873534 | http://purl.uniprot.org/core/pages | "5132-5138"xsd:string |
| http://purl.uniprot.org/citations/16873534 | http://purl.uniprot.org/core/title | "A quantitative trait locus on chromosome 6 regulates the onset of puberty in mice."xsd:string |
| http://purl.uniprot.org/citations/16873534 | http://purl.uniprot.org/core/volume | "147"xsd:string |
| http://purl.uniprot.org/citations/16873534 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16873534 |
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