| http://purl.uniprot.org/citations/16874301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16874301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16874301 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we have identified a novel mitochondrial ubiquitin ligase, designated MITOL, which is localized in the mitochondrial outer membrane. MITOL possesses a Plant Homeo-Domain (PHD) motif responsible for E3 ubiquitin ligase activity and predicted four-transmembrane domains. MITOL displayed a rapid degradation by autoubiquitination activity in a PHD-dependent manner. HeLa cells stably expressing a MITOL mutant lacking ubiquitin ligase activity or MITOL-deficient cells by small interfering RNA showed an aberrant mitochondrial morphology such as fragmentation, suggesting the enhancement of mitochondrial fission by MITOL dysfunction. Indeed, a dominant-negative expression of Drp1 mutant blocked mitochondrial fragmentation induced by MITOL depletion. We found that MITOL associated with and ubiquitinated mitochondrial fission protein hFis1 and Drp1. Pulse-chase experiment showed that MITOL overexpression increased turnover of these fission proteins. In addition, overexpression phenotype of hFis1 could be reverted by MITOL co-overexpression. Our finding indicates that MITOL plays a critical role in mitochondrial dynamics through the control of mitochondrial fission proteins."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601249"xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601249"xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Fukuda T."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Fukuda T."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Kyo S."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Kyo S."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Sada K."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Sada K."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Yamamura H."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Yamamura H."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Hotta H."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Hotta H."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Yanagi S."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Yanagi S."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Inatome R."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Inatome R."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Matsuki Y."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Matsuki Y."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Goto E."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Goto E."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Ishido S."xsd:string |
| http://purl.uniprot.org/citations/16874301 | http://purl.uniprot.org/core/author | "Ishido S."xsd:string |