| http://purl.uniprot.org/citations/16875667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16875667 | http://www.w3.org/2000/01/rdf-schema#comment | "High expression of PRL-3, a protein tyrosine phosphatase, is proved to be associated with lymph node metastasis in gastric carcinoma from previous studies. In this paper, we examined the relationship between PRL-3 expression and peritoneal metastasis in gastric carcinoma. We applied the artificial miRNA (pCMV-PRL3miRNA), which is based on the murine miR-155 sequence, to efficiently silence the target gene expression of PRL-3 in SGC7901 gastric cancer cells at both mRNA and protein levels. Then we observed that, in vitro, pCMV-PRL3miRNA significantly depressed the SGC7901 cell invasion and migration independent of cellular proliferation. In vivo, PRL-3 knockdown effectively suppressed the growth of peritoneal metastases and improved the prognosis in nude mice. Therefore, we concluded that artificial miRNA can depress the expression of PRL-3, and that PRL-3 might be a potential therapeutic target for gastric cancer peritoneal metastasis."xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.07.043"xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/author | "Zhu B."xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/author | "Cai S."xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/author | "Zhan W."xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/pages | "229-237"xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/title | "Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis."xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://purl.uniprot.org/core/volume | "348"xsd:string |
| http://purl.uniprot.org/citations/16875667 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16875667 |
| http://purl.uniprot.org/citations/16875667 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16875667 |
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| http://purl.uniprot.org/uniprot/#_Q9D658-mappedCitation-16875667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16875667 |
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| http://purl.uniprot.org/uniprot/Q4FK37 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16875667 |
| http://purl.uniprot.org/uniprot/Q9D658 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16875667 |