| http://purl.uniprot.org/citations/16876162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16876162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16876162 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor-alpha (TNF-alpha) induces the transcriptional activation of numerous genes involved in the inflammatory response. The recently identified protein TRUSS was investigated for its role in TNF-alpha-induced activation of c-Jun-NH(2) terminal kinase (JNK) and transcription factor, AP-1. Ectopic expression of TRUSS activated JNK and AP-1 in the absence and presence of TNF-alpha stimulation. The C-terminal region of TRUSS interacted with TNF receptor-associated factor-2 (TRAF2) and co-expression of dominant-inhibitory TRAF2 with TRUSS inhibited AP-1 activation, suggesting that TRUSS signaling occurs upstream of TRAF2. Further, a dominant-inhibitory mutant of TRUSS inhibited TNF-alpha-induced AP-1 activation. These findings suggest that TRUSS activates JNK in a TRAF2-dependent fashion and is involved in TNF-alpha-induced AP-1 activation via JNK kinases."xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2006.06.098"xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2006.06.098"xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/author | "Riches D.W.H."xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/author | "Riches D.W.H."xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/author | "Soond S.M."xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/author | "Soond S.M."xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/author | "Terry J.L."xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/author | "Terry J.L."xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/pages | "4591-4596"xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/pages | "4591-4596"xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/title | "TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1."xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/title | "TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1."xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/volume | "580"xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://purl.uniprot.org/core/volume | "580"xsd:string |
| http://purl.uniprot.org/citations/16876162 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16876162 |
| http://purl.uniprot.org/citations/16876162 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16876162 |
| http://purl.uniprot.org/citations/16876162 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16876162 |
| http://purl.uniprot.org/citations/16876162 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16876162 |