| http://purl.uniprot.org/citations/16877364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16877364 | http://www.w3.org/2000/01/rdf-schema#comment | "Currently, novel mouse models of melanoma are being generated that recapitulate the histopathology and molecular pathogenesis observed in human disease. Impaired cell-cycle control, which is a hallmark of both familial and sporadic melanoma, promotes slowly growing carcinogen-induced melanomas in the skin of mice carrying a mutated cyclin-dependent kinase 4 (CDK4(R24C)). Deregulated receptor tyrosine kinase signaling, which is another important feature of human melanoma, leads to spontaneous development of metastatic melanoma after a long latency period in mice overexpressing hepatocyte growth factor/scatter factor (HGF/SF mice). Here we report that treatment with 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate induced metastatic melanomas in all HGF/SF mice on the C57BL/6 background, which histologically resemble human melanoma. Importantly, mutant CDK4 dramatically increased the number and the growth kinetics of carcinogen-induced primary melanomas in the skin and promoted the growth of spontaneous metastases in lymph nodes and lungs in all HGF/SF mice within the first 3 months of life. Apart from very few skin papillomas, we did not observe tumors of other histology in carcinogen-treated HGF/SF x CDK4(R24C) mice. This new experimental mouse model can now be exploited to study further the biology of melanoma and evaluate new treatment modalities."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2006.060017"xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Ferrer A."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Buettner R."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Barbacid M."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Merlino G."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Malumbres M."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Wenzel J."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Basner-Tschakarjan E."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Tuting T."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Steitz J."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Gutgemann I."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Tormo D."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Gaffal E."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/author | "Heukamp L.C."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/pages | "665-672"xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/title | "Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation."xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://purl.uniprot.org/core/volume | "169"xsd:string |
| http://purl.uniprot.org/citations/16877364 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16877364 |
| http://purl.uniprot.org/citations/16877364 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16877364 |
| http://purl.uniprot.org/uniprot/#_E9Q9E4-mappedCitation-16877364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16877364 |
| http://purl.uniprot.org/uniprot/#_D3YWB0-mappedCitation-16877364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16877364 |