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http://purl.uniprot.org/citations/16879749http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16879749http://www.w3.org/2000/01/rdf-schema#comment"

Background

Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with HLA polymorphisms.

Methods

HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles were determined in 387 AAA cases (180 Belgian and 207 Canadian) and 426 controls (269 Belgian and 157 Canadian) by a PCR and single-strand oligonucleotide probe hybridization assay.

Results

We observed a potential association with the HLA-DQA1 locus among Belgian males (empirical p = 0.027, asymptotic p = 0.071). Specifically, there was a significant difference in the HLA-DQA1*0102 allele frequencies between AAA cases (67/322 alleles, 20.8%) and controls (44/356 alleles, 12.4%) in Belgian males (empirical p = 0.019, asymptotic p = 0.003). In haplotype analyses, marginally significant association was found between AAA and haplotype HLA-DQA1-DRB1 (p = 0.049 with global score statistics and p = 0.002 with haplotype-specific score statistics).

Conclusion

This study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.org/dc/terms/identifier"doi:10.1186/1471-2350-7-67"xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Lu Q."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Ogata T."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Skunca M."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Lancaster W.D."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Kuivaniemi H."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Sakalihasan N."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Tromp G."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Arthur C."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Sueda T."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Gregoire L."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Goddard K.A."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Limet R."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"MacKean G.L."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Shibamura H."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/author"Parrado A.R."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/name"BMC Med Genet"xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/pages"67"xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/title"Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study."xsd:string
http://purl.uniprot.org/citations/16879749http://purl.uniprot.org/core/volume"7"xsd:string
http://purl.uniprot.org/citations/16879749http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16879749
http://purl.uniprot.org/citations/16879749http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16879749
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