| http://purl.uniprot.org/citations/16880201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16880201 | http://www.w3.org/2000/01/rdf-schema#comment | "Translocation of the insulin-regulated glucose transporter GLUT4 to the cell surface is dependent on the phosphatidylinositol 3-kinase/Akt pathway. The RabGAP (Rab GTPase-activating protein) AS160 (Akt substrate of 160 kDa) is a direct substrate of Akt and plays an essential role in the regulation of GLUT4 trafficking. We have used liquid chromatography tandem mass spectrometry to identify several 14-3-3 isoforms as AS160-interacting proteins. 14-3-3 proteins interact with AS160 in an insulin- and Akt-dependent manner via an Akt phosphorylation site, Thr-642. This correlates with the dominant negative effect of both the AS160(T642A) and the AS160(4P) mutants on insulin-stimulated GLUT4 translocation. Introduction of a constitutive 14-3-3 binding site into AS160(4P) restored 14-3-3 binding without disrupting AS160-IRAP (insulin-responsive amino peptidase) interaction and reversed the inhibitory effect of AS160(4P) on GLUT4 translocation. These data show that the insulin-dependent association of 14-3-3 with AS160 plays an important role in GLUT4 trafficking in adipocytes."xsd:string |
| http://purl.uniprot.org/citations/16880201 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m603274200"xsd:string |
| http://purl.uniprot.org/citations/16880201 | http://purl.uniprot.org/core/author | "Guilhaus M."xsd:string |
| http://purl.uniprot.org/citations/16880201 | http://purl.uniprot.org/core/author | "James D.E."xsd:string |
| http://purl.uniprot.org/citations/16880201 | http://purl.uniprot.org/core/author | "Larance M."xsd:string |
| http://purl.uniprot.org/citations/16880201 | http://purl.uniprot.org/core/author | "Ramm G."xsd:string |
| http://purl.uniprot.org/citations/16880201 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16880201 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16880201 | http://purl.uniprot.org/core/pages | "29174-29180"xsd:string |
| http://purl.uniprot.org/citations/16880201 | http://purl.uniprot.org/core/title | "A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160."xsd:string |
| http://purl.uniprot.org/citations/16880201 | http://purl.uniprot.org/core/volume | "281"xsd:string |
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