| http://purl.uniprot.org/citations/16882874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16882874 | http://www.w3.org/2000/01/rdf-schema#comment | "The macrophage Class A scavenger receptor MARCO (macrophage receptor with a collagenous structure) functions as a pattern-recognition receptor for bacterial components, but its role in responses to CpG oligonucleotide sequences (CpG-ODN) in microbial DNA has not been characterized. Phosphorothioate (PS)-linked CpG-ODN stimulated IL-12 and NO production in wild-type but not in MARCO-deficient, thioglycollate-elicited peritoneal macrophages. MARCO and the related class A receptor SR-A belong to a redundant system of receptors for PS ODNs. The ability of MARCO to bind CpG-ODNs and conversely, to costimulate IL-12 and NO production upon specific ligation with immobilized mAb is consistent with MARCO being a signaling receptor for CpG-ODNs, costimulating TLR9-mediated NO and IL-12 production in macrophages. In contrast to MARCO, SR-A is likely to mediate negative regulation of macrophage responses to CpG-ODNs. In particular, increased affinity toward SR-A may contribute to decreased potency of oligo G-modified CpG-ODNs in stimulating IL-12 production. The results suggest that differential involvement of activating and inhibitory membrane receptors, such as SR-A and MARCO, may underlie profound differences observed in biological activities of different ODN sequences."xsd:string |
| http://purl.uniprot.org/citations/16882874 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0705357"xsd:string |
| http://purl.uniprot.org/citations/16882874 | http://purl.uniprot.org/core/author | "Kobzik L."xsd:string |
| http://purl.uniprot.org/citations/16882874 | http://purl.uniprot.org/core/author | "Sulahian T.H."xsd:string |
| http://purl.uniprot.org/citations/16882874 | http://purl.uniprot.org/core/author | "Arredouani M."xsd:string |
| http://purl.uniprot.org/citations/16882874 | http://purl.uniprot.org/core/author | "Jozefowski S."xsd:string |
| http://purl.uniprot.org/citations/16882874 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16882874 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/16882874 | http://purl.uniprot.org/core/pages | "870-879"xsd:string |
| http://purl.uniprot.org/citations/16882874 | http://purl.uniprot.org/core/title | "Role of scavenger receptor MARCO in macrophage responses to CpG oligodeoxynucleotides."xsd:string |
| http://purl.uniprot.org/citations/16882874 | http://purl.uniprot.org/core/volume | "80"xsd:string |
| http://purl.uniprot.org/citations/16882874 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16882874 |
| http://purl.uniprot.org/citations/16882874 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16882874 |
| http://purl.uniprot.org/uniprot/#_A0A087WS94-mappedCitation-16882874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16882874 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRS5-mappedCitation-16882874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16882874 |
| http://purl.uniprot.org/uniprot/#_A2RT24-mappedCitation-16882874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16882874 |
| http://purl.uniprot.org/uniprot/#_Q3TXV5-mappedCitation-16882874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16882874 |
| http://purl.uniprot.org/uniprot/#_Q3U105-mappedCitation-16882874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16882874 |
| http://purl.uniprot.org/uniprot/#_Q3U2C3-mappedCitation-16882874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16882874 |
| http://purl.uniprot.org/uniprot/#_Q8CED7-mappedCitation-16882874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16882874 |
| http://purl.uniprot.org/uniprot/#_P30204-mappedCitation-16882874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16882874 |
| http://purl.uniprot.org/uniprot/#_Q3TF99-mappedCitation-16882874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16882874 |
| http://purl.uniprot.org/uniprot/#_Q60754-mappedCitation-16882874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16882874 |
| http://purl.uniprot.org/uniprot/#_Q3U3E5-mappedCitation-16882874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16882874 |