| http://purl.uniprot.org/citations/16884531 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16884531 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundOtitis media is one of the most common infections of early childhood. Surfactant protein A functions as part of the innate immune response, which plays an important role in preventing infections early in life. This prospective study utilized a candidate gene approach to evaluate the association between polymorphisms in loci encoding SP-A and risk of otitis media during the first year of life among a cohort of infants at risk for developing asthma.MethodsBetween September 1996 and December 1998, women were invited to participate if they had at least one other child with physician-diagnosed asthma. Each mother was given a standardized questionnaire within 4 months of her infant's birth. Infant respiratory symptoms were collected during quarterly telephone interviews at 6, 9 and 12 months of age. Genotyping was done on 355 infants for whom whole blood and complete otitis media data were available.ResultsPolymorphisms at codons 19, 62, and 133 in SP-A1, and 223 in SP-A2 were associated with race/ethnicity. In logistic regression models incorporating estimates of uncertainty in haplotype assignment, the 6A4/1A5haplotype was protective for otitis media among white infants in our study population (OR 0.23; 95% CI 0.07,0.73).ConclusionThese results indicate that polymorphisms within SP-A loci may be associated with otitis media in white infants. Larger confirmatory studies in all ethnic groups are warranted."xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.org/dc/terms/identifier | "doi:10.1186/1471-2350-7-68"xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/author | "Belanger K.D."xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/author | "Bracken M.B."xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/author | "Pettigrew M.M."xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/author | "Holford T.R."xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/author | "Leaderer B.P."xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/author | "Triche E.W."xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/author | "Gent J.F."xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/name | "BMC Med Genet"xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/pages | "68"xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/title | "Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma."xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/16884531 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16884531 |
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| http://purl.uniprot.org/uniprot/#_B4DNW5-mappedCitation-16884531 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16884531 |
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