| http://purl.uniprot.org/citations/16885027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16885027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16885027 | http://www.w3.org/2000/01/rdf-schema#comment | "Histone methylation regulates diverse chromatin-templated processes, including transcription. Many transcriptional corepressor complexes contain lysine-specific demethylase 1 (LSD1) and CoREST that collaborate to demethylate mono- and dimethylated H3-K4 of nucleosomes. Here, we report the crystal structure of the LSD1-CoREST complex. LSD1-CoREST forms an elongated structure with a long stalk connecting the catalytic domain of LSD1 and the CoREST SANT2 domain. LSD1 recognizes a large segment of the H3 tail through a deep, negatively charged pocket at the active site and possibly a shallow groove on its surface. CoREST SANT2 interacts with DNA. Disruption of the SANT2-DNA interaction diminishes CoREST-dependent demethylation of nucleosomes by LSD1. The shape and dimension of LSD1-CoREST suggest its bivalent binding to nucleosomes, allowing efficient H3-K4 demethylation. This spatially separated, multivalent nucleosome binding mode may apply to other chromatin-modifying enzymes that generally contain multiple nucleosome binding modules."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2006.07.012"xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2006.07.012"xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Luo X."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Luo X."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Tomchick D.R."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Tomchick D.R."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Yang M."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Yang M."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Borek D."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Borek D."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Machius M."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Machius M."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Otwinowski Z."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Otwinowski Z."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Gocke C.B."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/author | "Gocke C.B."xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16885027 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |