| http://purl.uniprot.org/citations/16887971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16887971 | http://www.w3.org/2000/01/rdf-schema#comment | "The mouse multimember family of Qa-2 oligomorphic class I MHC genes is continuously undergoing duplications and deletions that alter the number of the two "prototype" Qa-2 sequences, Q8 and Q9. The frequent recombination events within the Q region lead to strain-specific modulation of the cumulative Qa-2 expression levels. Q9 protects C57BL/6 hosts from multiple disparate tumors and functions as a major CTL restriction element for shared tumor-associated Ags. We have now analyzed functional and structural properties of Q8, a class I MHC that differs significantly from Q9 in the peptide-binding, CTL-interacting alpha(1) and alpha(2) regions. Unexpectedly, we find that the extracellular domains of Q8 and Q9 act similarly during primary and secondary rejection of tumors, are recognized by cross-reactive antitumor CTL, have overlapping peptide-binding motifs, and are both assembled via the transporter associated with the Ag processing pathway. These findings suggest that shared Ag-presenting functions of the "odd" and "even" Qa-2 loci may contribute to the selective pressures shaping the haplotype-dependent quantitative variation of Qa-2 protein expression."xsd:string |
| http://purl.uniprot.org/citations/16887971 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.4.2123"xsd:string |
| http://purl.uniprot.org/citations/16887971 | http://purl.uniprot.org/core/author | "Stroynowski I."xsd:string |
| http://purl.uniprot.org/citations/16887971 | http://purl.uniprot.org/core/author | "Chiang E.Y."xsd:string |
| http://purl.uniprot.org/citations/16887971 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16887971 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16887971 | http://purl.uniprot.org/core/pages | "2123-2130"xsd:string |
| http://purl.uniprot.org/citations/16887971 | http://purl.uniprot.org/core/title | "The role of structurally conserved class I MHC in tumor rejection: contribution of the Q8 locus."xsd:string |
| http://purl.uniprot.org/citations/16887971 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/16887971 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16887971 |
| http://purl.uniprot.org/citations/16887971 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16887971 |
| http://purl.uniprot.org/uniprot/#_P79567-mappedCitation-16887971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16887971 |
| http://purl.uniprot.org/uniprot/#_Q31223-mappedCitation-16887971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16887971 |
| http://purl.uniprot.org/uniprot/#_Q62143-mappedCitation-16887971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16887971 |
| http://purl.uniprot.org/uniprot/#_Q52PG7-mappedCitation-16887971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16887971 |
| http://purl.uniprot.org/uniprot/#_P14430-mappedCitation-16887971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16887971 |
| http://purl.uniprot.org/uniprot/#_P14431-mappedCitation-16887971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16887971 |
| http://purl.uniprot.org/uniprot/P14430 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16887971 |
| http://purl.uniprot.org/uniprot/P14431 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16887971 |
| http://purl.uniprot.org/uniprot/Q52PG7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16887971 |
| http://purl.uniprot.org/uniprot/Q62143 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16887971 |
| http://purl.uniprot.org/uniprot/P79567 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16887971 |
| http://purl.uniprot.org/uniprot/Q31223 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16887971 |