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| http://purl.uniprot.org/citations/16890216 | http://www.w3.org/2000/01/rdf-schema#comment | "Serotonin (5-HT) stimulation of egg-laying in Caenorhabditis elegans is abolished in ser-1 (ok345) animals and is rescued by ser-1 expression in vulval muscle. A PDZ binding motif (ETFL) at the SER-1 C-terminus is not essential for rescue, but facilitates SER-1 signaling. SER-1 binds specifically to PDZ domain 10 of the multi-PDZ domain protein, MPZ-1, based on GST pulldown and co-immunoprecipitation. mpz-1 is expressed in about 60 neurons and body wall and vulval muscles. In neurons, GFP-tagged MPZ-1 is punctate and colocalizes with the synaptic marker, synaptobrevin. The expression patterns of ser-1 and mpz-1 overlap in 3 pairs of neurons and vulval muscle. In addition, MPZ-1 also interacts with other GPCRs with acidic amino acids in the -3 position of their PDZ binding motifs. mpz-1 RNAi reduces 5-HT stimulated egg-laying in wild type animals and in ser-1 mutants rescued by muscle expression of SER-1. In contrast, mpz-1 RNAi has no effect on 5-HT stimulated egg-laying in ser-1 mutants rescued by expression of a truncated SER-1 that lacks the C-terminal PDZ binding motif. The overexpression of MPZ-1 PDZ domain 10 also inhibits 5-HT stimulated egg-laying. These studies suggest that the SER-1/MPZ-1 interaction facilitates SER-1 mediated signaling."xsd:string |
| http://purl.uniprot.org/citations/16890216 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2006.06.044"xsd:string |
| http://purl.uniprot.org/citations/16890216 | http://purl.uniprot.org/core/author | "Lin L."xsd:string |
| http://purl.uniprot.org/citations/16890216 | http://purl.uniprot.org/core/author | "Smith K.A."xsd:string |
| http://purl.uniprot.org/citations/16890216 | http://purl.uniprot.org/core/author | "Xiao H."xsd:string |
| http://purl.uniprot.org/citations/16890216 | http://purl.uniprot.org/core/author | "Komuniecki R."xsd:string |
| http://purl.uniprot.org/citations/16890216 | http://purl.uniprot.org/core/author | "Plenefisch J."xsd:string |
| http://purl.uniprot.org/citations/16890216 | http://purl.uniprot.org/core/author | "Hapiak V.M."xsd:string |
| http://purl.uniprot.org/citations/16890216 | http://purl.uniprot.org/core/author | "Hobson R.J."xsd:string |
| http://purl.uniprot.org/citations/16890216 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16890216 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/16890216 | http://purl.uniprot.org/core/pages | "379-391"xsd:string |
| http://purl.uniprot.org/citations/16890216 | http://purl.uniprot.org/core/title | "SER-1, a Caenorhabditis elegans 5-HT2-like receptor, and a multi-PDZ domain containing protein (MPZ-1) interact in vulval muscle to facilitate serotonin-stimulated egg-laying."xsd:string |
| http://purl.uniprot.org/citations/16890216 | http://purl.uniprot.org/core/volume | "298"xsd:string |
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