| http://purl.uniprot.org/citations/16890542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16890542 | http://www.w3.org/2000/01/rdf-schema#comment | "Granuphilin is a crucial component of the docking machinery of insulin-containing vesicles to the plasma membrane. Here, we show that the granuphilin promoter is a target of SREBP-1c, a transcription factor that controls fatty acid synthesis, and MafA, a beta cell differentiation factor. Potassium-stimulated insulin secretion (KSIS) was suppressed in islets with adenoviral-mediated overexpression of granuphilin and enhanced in islets with knockdown of granuphilin (in which granuphilin had been knocked down). SREBP-1c and granuphilin were activated in islets from beta cell-specific SREBP-1c transgenic mice, as well as in several diabetic mouse models and normal islets treated with palmitate, accompanied by a corresponding reduction in insulin secretion. Knockdown- or knockout-mediated ablation of granuphilin or SREBP-1c restored KSIS in these islets. Collectively, our data provide evidence that activation of the SREBP-1c/granuphilin pathway is a potential mechanism for impaired insulin secretion in diabetes, contributing to beta cell lipotoxicity."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2006.06.009"xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Endo Y."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Izumi T."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Kato T."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Nakagawa Y."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Takahashi S."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Yamada N."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Shimano H."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Sone H."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Takahashi A."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Ishikawa M."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Toyoshima H."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Yokoo T."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Gomi H."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Hasty A.H."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Kumadaki S."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Matsuzaka T."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/author | "Yahagi N."xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/16890542 | http://purl.uniprot.org/core/pages | "143-154"xsd:string |