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http://purl.uniprot.org/citations/1689298http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1689298http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1689298http://www.w3.org/2000/01/rdf-schema#comment"Mouse liver RNA analyzed by Northern blotting with a full-length complement factor H cDNA probe demonstrates the 4.4-kilobase (kb) H mRNA as well as three additional hybridizing species of 3.5, 2.8, and 1.8 kb, respectively. Further characterization of these alternative transcripts was pursued by isolation of additional cDNAs from a liver library using a full-length H probe. Twelve clones homologous to but distinct from H were isolated, analyzed by restriction mapping, and divided into four classes, A, B, C, and D, based on their sequences. Clones from classes A, B, and C all contained nearly identical 5'-untranslated regions and leader sequences that differed from H at more than 50% of their nucleotide positions. The 5'-untranslated and leader sequences of the class D clone were unrelated to the corresponding regions of H or the class A, B, or C clones. The remaining portions of the H-related cDNAs were made up of short consensus repeats, 7 in class A, 4 in class B, 13 in class C, and 5 in class D. To determine the relationship between the H-related transcripts and the cDNA clones, Northern blots of liver RNA were analyzed by hybridization with two probes, one specific for the class D cDNA and the other reacting specifically with the class A, B, and C cDNAs. The class A/B/C probe detected transcripts of 3.5, 2.8, and 1.8 kb in liver RNA, and the class D probe hybridized to a distinct 1.8-kb message. Additionally, a cosmid genomic library was screened with H cDNA, and nine H-related clones were isolated. They spanned a region of approximately 120 kb, defining at least two discrete H-related gene loci. These results identify new members of the super-family of C3b/C4b binding protein genes."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.org/dc/terms/identifier"doi:10.1016/s0021-9258(19)39753-4"xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/author"Chaplin D.D."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/author"Chaplin D.D."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/author"Tack B.F."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/author"Tack B.F."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/author"Vik D.P."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/author"Vik D.P."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/author"Munoz-Canoves P."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/author"Munoz-Canoves P."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/author"Kozono H."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/author"Kozono H."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/author"Martin L.G."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/author"Martin L.G."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/date"1990"xsd:gYear
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/date"1990"xsd:gYear
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/name"J Biol Chem"xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/pages"3193-3201"xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/pages"3193-3201"xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/title"Identification and sequence analysis of four complement factor H-related transcripts in mouse liver."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/title"Identification and sequence analysis of four complement factor H-related transcripts in mouse liver."xsd:string
http://purl.uniprot.org/citations/1689298http://purl.uniprot.org/core/volume"265"xsd:string