| http://purl.uniprot.org/citations/16895968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16895968 | http://www.w3.org/2000/01/rdf-schema#comment | "The interaction of non-muscle myosins 2A and 2B with actin may drive changes in cell movement, shape and adhesion. To investigate this, we used cultured myoblasts as a model system. These cells characteristically change shape from triangular to bipolar when they form groups of aligned cells. Antisense oligonucleotide knockdown of non-muscle myosin 2A, but not non-muscle myosin 2B, inhibited this shape change, interfered with cell-cell adhesion, had a minor effect on tail retraction and prevented myoblast fusion. By contrast, non-muscle myosin 2B knockdown markedly inhibited tail retraction, increasing cell length by over 200% by 72 hours compared with controls. In addition it interfered with nuclei redistribution in myotubes. Non-muscle myosin 2C is not involved as western analysis showed that it is not expressed in myoblasts, but only in myotubes. To understand why non-muscle myosins 2A and 2B have such different roles, we analysed their distributions by immuno-electron microscopy, and found that non-muscle myosin 2A was more tightly associated with the plasma membrane than non-muscle myosin 2B. This suggests that non-muscle myosin 2A is more important for bipolar shape formation and adhesion owing to its preferential interaction with membrane-associated actin, whereas the role of non-muscle myosin 2B in retraction prevents over-elongation of myoblasts."xsd:string |
| http://purl.uniprot.org/citations/16895968 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.03096"xsd:string |
| http://purl.uniprot.org/citations/16895968 | http://purl.uniprot.org/core/author | "Peckham M."xsd:string |
| http://purl.uniprot.org/citations/16895968 | http://purl.uniprot.org/core/author | "Knight P.J."xsd:string |
| http://purl.uniprot.org/citations/16895968 | http://purl.uniprot.org/core/author | "Colegrave M."xsd:string |
| http://purl.uniprot.org/citations/16895968 | http://purl.uniprot.org/core/author | "Swailes N.T."xsd:string |
| http://purl.uniprot.org/citations/16895968 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16895968 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/16895968 | http://purl.uniprot.org/core/pages | "3561-3570"xsd:string |
| http://purl.uniprot.org/citations/16895968 | http://purl.uniprot.org/core/title | "Non-muscle myosins 2A and 2B drive changes in cell morphology that occur as myoblasts align and fuse."xsd:string |
| http://purl.uniprot.org/citations/16895968 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/16895968 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16895968 |
| http://purl.uniprot.org/citations/16895968 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16895968 |
| http://purl.uniprot.org/uniprot/Q8VDD5#attribution-0F9FD1C248392C5612723AF3038D4F09 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16895968 |
| http://purl.uniprot.org/uniprot/Q8VDD5#attribution-5F87AE05132A3C4C223F6C21AA5006F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16895968 |
| http://purl.uniprot.org/uniprot/Q61879#attribution-0F9FD1C248392C5612723AF3038D4F09 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16895968 |
| http://purl.uniprot.org/uniprot/Q61879#attribution-5F87AE05132A3C4C223F6C21AA5006F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16895968 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VKI5-mappedCitation-16895968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16895968 |
| http://purl.uniprot.org/uniprot/#_A0A2R8W6V7-mappedCitation-16895968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16895968 |
| http://purl.uniprot.org/uniprot/#_A2VCK0-mappedCitation-16895968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16895968 |
| http://purl.uniprot.org/uniprot/#_F2Z494-mappedCitation-16895968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16895968 |
| http://purl.uniprot.org/uniprot/#_Q14B05-mappedCitation-16895968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16895968 |
| http://purl.uniprot.org/uniprot/#_G3UW82-mappedCitation-16895968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16895968 |
| http://purl.uniprot.org/uniprot/#_I6L963-mappedCitation-16895968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16895968 |