| http://purl.uniprot.org/citations/16896160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16896160 | http://www.w3.org/2000/01/rdf-schema#comment | "The histone deacetylase inhibitors (HDA-CIs) butyrate and trichostatin A activate gamma-globin expression via a p38 mitogen-activating protein kinase (MAPK)-dependent mechanism. We hypothesized that down-stream effectors of p38 MAPK, namely activating transcription factor-2 (ATF-2) and cyclic AMP response element (CRE) binding protein (CREB), are intimately involved in fetal hemoglobin induction by these agents. In this study, we observed increased ATF-2 and CREB1 phosphorylation mediated by the HDACIs in K562 cells, in conjunction with histone H4 hyperacetylation. Moreover, enhanced DNA-protein interactions occurred in the CRE in the (G)gamma-globin promoter (G-CRE) in vitro after drug treatments; subsequent chromatin immunoprecipitation assay confirmed ATF-2 and CREB1 binding to the G-CRE in vivo. Enforced expression of ATF-2 and CREB produced (G)gamma-promoter trans-activation which was abolished by a 2-base pair mutation in the putative G-CRE. The data presented herein demonstrate that gamma-gene induction by butyrate and trichostatin A involves ATF-2 and CREB1 activation via p38 MAPK signaling."xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-01-023713"xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/author | "Lee M.S."xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/author | "Yao X."xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/author | "Pace B.S."xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/author | "Hsiao C.H."xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/author | "Sangerman J."xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/author | "Ofori-Acquah S.F."xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/author | "Oteng E."xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/author | "Zein S."xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/pages | "3590-3599"xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/title | "Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2."xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/16896160 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16896160 |
| http://purl.uniprot.org/citations/16896160 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16896160 |
| http://purl.uniprot.org/uniprot/#_P15336-mappedCitation-16896160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16896160 |
| http://purl.uniprot.org/uniprot/#_B7Z7P1-mappedCitation-16896160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16896160 |
| http://purl.uniprot.org/uniprot/#_A4D7U3-mappedCitation-16896160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16896160 |
| http://purl.uniprot.org/uniprot/#_A4D7U7-mappedCitation-16896160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16896160 |
| http://purl.uniprot.org/uniprot/#_A4D7U9-mappedCitation-16896160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16896160 |
| http://purl.uniprot.org/uniprot/#_A4D7V5-mappedCitation-16896160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16896160 |