| http://purl.uniprot.org/citations/16897186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16897186 | http://www.w3.org/2000/01/rdf-schema#comment | "Mucinous and clear cell adenocarcinomas are the major histological types of ovarian epithelial cancer and are associated with a poor prognosis due to their resistance to chemotherapy. A novel tumor marker specific for ovarian mucinous and clear cell adenocarcinomas would be helpful for overcoming these serious diseases. We showed previously by enzymological characterization and RT-PCR that colonic mucinous adenocarcinoma tissues ectopically express GlcNAc6ST-2, a member of the carbohydrate 6-O-sulfotransferase family (Seko, A. et al. (2002) Glycobiology 12, 379-388). Here, we prepared a GlcNAc6ST-2-specific polyclonal antibody for immunohistochemical analysis and found that GlcNAc6ST-2 is ectopically expressed by not only colonic mucinous adenocarcinomas but also ovarian mucinous, clear cell and papillary serous adenocarcinomas. In contrast, solid serous adenocarcinomas, endometrioid adenocarcinomas, and mucinous adenomas expressed GlcNAc6ST-2 much less frequently or not at all. RT-PCR analysis confirmed that GlcNAc6ST-2 transcripts are expressed in ovarian mucinous adenocarcinomas but not in mucinous adenomas. In addition, immunohistochemical analysis using sulfated glycan-specific monoclonal antibodies showed that ovarian adenocarcinoma cells express GlcNAc 6-O-sulfated glycans, including an L-selectin ligand and its related glycans. These results indicate that GlcNAc6ST-2 would be a novel tumor antigen that is specifically expressed in ovarian mucinous, clear cell and papillary serous adenocarcinomas."xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10719-006-6979-6"xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/author | "Yoshida M."xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/author | "Yamashita K."xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/author | "Sakamoto M."xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/author | "Nomoto M."xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/author | "Yonezawa S."xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/author | "Seko A."xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/author | "Kanoh A."xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/author | "Kannagi R."xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/author | "Ideo H."xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/name | "Glycoconj J"xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/pages | "453-460"xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/title | "Ectopic expression of N-acetylglucosamine 6-O-sulfotransferase 2 in chemotherapy-resistant ovarian adenocarcinomas."xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/16897186 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16897186 |
| http://purl.uniprot.org/citations/16897186 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16897186 |
| http://purl.uniprot.org/uniprot/#_B3KN17-mappedCitation-16897186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16897186 |
| http://purl.uniprot.org/uniprot/#_Q9Y4C5-mappedCitation-16897186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16897186 |
| http://purl.uniprot.org/uniprot/#_V9HVX9-mappedCitation-16897186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16897186 |
| http://purl.uniprot.org/uniprot/Q9Y4C5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16897186 |
| http://purl.uniprot.org/uniprot/V9HVX9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16897186 |
| http://purl.uniprot.org/uniprot/B3KN17 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16897186 |